Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results

doi:10.1016/j.ijpharm.2008.08.004

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	Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results
	Gan, Li 1,2; Gan, Yong1 ; Zhu, Chunliu1 ; Zhang, Xinxin1 ; Zhu, Jiabi 2
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2009-01-05
卷号	365 期号:1-2 页码:143-149
关键词	Cyclosporine A Microemulsion In situ gelling system Kelcogel (R) Ophthalmic delivery
ISSN号	0378-5173
DOI	10.1016/j.ijpharm.2008.08.004
文献子类	Article
英文摘要	The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded microemulsion was prepared using castor oil, Solutol HS 15 (surfactant), glycerol and water. This microemulsion was then dispersed in a Kelcogel (R) solution to form the final microemulsion in situ electrolyte-triggered gelling system. In vitro, the viscosity of the CsA microemulsion Kelcogel (R) system increased dramatically on dilution with artificial tear fluid and exhibited pseudo-plastic rheology. In vivo results revealed that the AUC(0-->32h) of corneal CsA for the microemulsion Kelcogel (R) system was approximately three-fold greater than for a CsA emulsion. Moreover, at 32 h after administration, CsA concentrations delivered by the microemulsion Kelcogel (R) system remained at therapeutic levels in the cornea. This CsA microemulsion in situ electrolyte-triggered gelling system might provide an alternative approach to deliver prolonged precorneal residence time of CsA for preventing cornea allograft rejection. Published by Elsevier B.V.
资助项目	National High Technology Research and Development Program of China[2007AA021604]
WOS关键词	OCULAR DRUG-DELIVERY ; GELLAN GUM ; EYE ; VEHICLES ; POLYMERS ; RABBITS ; CELLS ; PH
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000262546700020
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279344]
专题	药物制剂研究中心
通讯作者	Gan, Yong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China
推荐引用方式 GB/T 7714	Gan, Li,Gan, Yong,Zhu, Chunliu,et al. Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2009,365(1-2):143-149.
APA	Gan, Li,Gan, Yong,Zhu, Chunliu,Zhang, Xinxin,&Zhu, Jiabi.(2009).Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results.INTERNATIONAL JOURNAL OF PHARMACEUTICS,365(1-2),143-149.
MLA	Gan, Li,et al."Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: In vitro and in vivo results".INTERNATIONAL JOURNAL OF PHARMACEUTICS 365.1-2(2009):143-149.