Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles

doi:10.1002/smll.200900923

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles
	He, Qianjun 1; Zhang, Zhiwen2 ; Gao, Yu 2; Shi, Jianlin 1; Li, Yaping2
刊名	SMALL
	2009-12-04
卷号	5 期号:23 页码:2722-2729
关键词	cytotoxicity intracellular localization mesoporous silica microparticles spherical nanoparticles
ISSN号	1613-6810
DOI	10.1002/smll.200900923
文献子类	Article
英文摘要	This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.
资助项目	National Nature Science Foundation of China[20633090] ; National Nature Science Foundation of China[50823007] ; National 863 High-Tech Program[2007AA03Z317] ; Shanghai Rising-Star Progrom[07QA14061] ; Shanghai Nano-Science Project[0852nm03900] ; CASKJCX[KJCX2-YW-M02] ; CASKJCX[KJCX2-YW-210]
WOS关键词	DRUG-DELIVERY SYSTEMS ; CONTROLLED-RELEASE ; EPITHELIAL-CELLS ; NANOPARTICLES ; PARTICLES ; MICELLES ; SURFACE ; CRYSTALLINE ; MACROPHAGES ; MECHANISMS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000272671900016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279066]
专题	药物制剂研究中心
通讯作者	Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	He, Qianjun,Zhang, Zhiwen,Gao, Yu,et al. Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles[J]. SMALL,2009,5(23):2722-2729.
APA	He, Qianjun,Zhang, Zhiwen,Gao, Yu,Shi, Jianlin,&Li, Yaping.(2009).Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles.SMALL,5(23),2722-2729.
MLA	He, Qianjun,et al."Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles".SMALL 5.23(2009):2722-2729.