Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography

doi:10.1016/j.ijpharm.2012.02.017

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	Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography
	Li, Haiyan2 ; Yin, Xianzhen 2; Ji, Junqiu 3; Sun, Lixin 4; Shao, Qun 1; York, Peter 1; Xiao, Tiqiao 5; He, You 5; Zhang, Jiwen2
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2012-05-10
卷号	427 期号:2 页码:270-275
关键词	Osmotic drug delivery system Synchrotron radiation X-ray computed Microtomography Three dimensional reconstruction Drug release kinetics Surface area
ISSN号	0378-5173
DOI	10.1016/j.ijpharm.2012.02.017
文献子类	Article
英文摘要	Tomographic imaging techniques are attractive tools for the visualization of the internal structural characteristics of pharmaceutical solid dosage forms. In this paper, the internal structure of the tablet core for a monolith osmotic drug delivery system, felodipine sustained-release tablet, was visualized via synchrotron radiation X-ray computed microtomography during the drug release process. The surface areas and three dimensional parameters of the tablet core were calculated based on the three dimensional reconstruction of the images. At different stages of the drug release process, the surface morphology, the hydration, the swelling, and the structure changing of the tablet, were visualized from the two dimensional monochrome X-ray images. The three dimensional volumes of the remaining tablet core correlated well with the percentages of felodipine (R = 0.9988). Also, the three dimensional surface area almost unchanged during the drug release process, which clearly demonstrated the intrinsic drug release mechanism of the osmotic drug delivery system. In conclusion, the synchrotron radiation X-ray computed microtomography, with rapid acquisition, high intensity and micro-scale spatial resolution, was found to be a useful tool for the quantitative elucidation of the intrinsic drug release kinetics and the three dimensional parameters such as surface areas of the remained core obtained by the synchrotron radiation. Thus, X-ray computed microtomography can be considered as a new and complimentary analytical tool to standard compendial pharmaceutical tests for quality control of osmotic drug delivery systems. (C) 2012 Elsevier B.V. All rights reserved.
资助项目	Ministry of Science and Technology of China[2009ZX09301-001] ; Ministry of Science and Technology of China[2008ZX09401-004] ; International Science & Technology Cooperation Project[S2010GR0920] ; Engineering and Physical Sciences Research Council[EP/K004204/1] ; Engineering and Physical Sciences Research Council[EP/G042365/1]
WOS关键词	ORAL-DRUG DELIVERY ; COMPUTED-TOMOGRAPHY ; SYSTEM ; NIFEDIPINE ; FORM
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000302364500016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278079]
专题	药物制剂研究中心
通讯作者	Zhang, Jiwen
作者单位	1.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 3.Hefei Lifeon Medicat Grp, Hefei 230088, Peoples R China; 4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
推荐引用方式 GB/T 7714	Li, Haiyan,Yin, Xianzhen,Ji, Junqiu,et al. Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2012,427(2):270-275.
APA	Li, Haiyan.,Yin, Xianzhen.,Ji, Junqiu.,Sun, Lixin.,Shao, Qun.,...&Zhang, Jiwen.(2012).Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography.INTERNATIONAL JOURNAL OF PHARMACEUTICS,427(2),270-275.
MLA	Li, Haiyan,et al."Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography".INTERNATIONAL JOURNAL OF PHARMACEUTICS 427.2(2012):270-275.