Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer

doi:10.1016/j.biomaterials.2013.08.056

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	Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer
	Xiao, Jisheng 2; Duan, Xiaopin 1,2; Yin, Qi2 ; Zhang, Zhiwen2 ; Yu, Haijun2 ; Li, Yaping2
刊名	BIOMATERIALS
	2013-12
卷号	34 期号:37 页码:9648-9656
关键词	Nanodiamonds Doxorubicin Drug delivery Metastasis Breast cancer
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2013.08.056
文献子类	Article
英文摘要	Lung metastasis is one of the greatest challenges for breast cancer treatment. Here, a nanodiamonds (NDs)-mediated doxorubicin (DOX) delivery system was first designed to inhibit the lung metastasis of breast cancer effectively. DOX was non-covalently bound to NDs via physical adsorption in an aqueous solution, then DSPE-PEG 2K was coated to the NDs-DOX complex (NDX) to increase the dispersibility and prolong the circulation time. DSPE-PEG 2K coating NDX (DNX) displayed high drug loading and excellent ability to deliver DOX to the nucleus, thereby significantly enhancing cytotoxicity and inducing cell apoptosis. Furthermore, DNX showed good histocompatibility and could improve drug accumulation in lung, as a result, markedly inhibited the lung metastasis of breast cancer. The high anti-metastasis efficacy with the decreased systemic toxicity suggested that DNX could be a promising drug delivery system for the therapy of lung metastasis of breast cancer. (C) 2013 Elsevier Ltd. All rights reserved.
资助项目	National Basic Research Program of China[2010C B934000] ; National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[30925041] ; National Natural Science Foundation of China[81270047] ; Shanghai program[12nm0501300]
WOS关键词	DRUG-DELIVERY ; SIRNA DELIVERY ; NANOPARTICLES ; SYSTEMS ; CELLS ; POLYETHYLENIMINE ; BIODISTRIBUTION ; VEHICLES ; GROWTH
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000326901200041
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277361]
专题	药物制剂研究中心
通讯作者	Li, Yaping
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xiao, Jisheng,Duan, Xiaopin,Yin, Qi,et al. Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer[J]. BIOMATERIALS,2013,34(37):9648-9656.
APA	Xiao, Jisheng,Duan, Xiaopin,Yin, Qi,Zhang, Zhiwen,Yu, Haijun,&Li, Yaping.(2013).Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer.BIOMATERIALS,34(37),9648-9656.
MLA	Xiao, Jisheng,et al."Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer".BIOMATERIALS 34.37(2013):9648-9656.