Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway

doi:10.3892/ijo.2013.2107

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway
	Xu, Marvin Xuejun 5; Zhao, Linlin 4; Deng, Chaoyang 4; Yang, Lu 4; Wang, Yang 3; Guo, Tao 2; Li, Lifang 3; Lin, Jianping 1; Zhang, Lirong 5
刊名	INTERNATIONAL JOURNAL OF ONCOLOGY
	2013-12
卷号	43 期号:6 页码:1951-1959
关键词	curcumin Wnt signaling pathway hepatocellular carcinoma
ISSN号	1019-6439
DOI	10.3892/ijo.2013.2107
文献子类	Article
英文摘要	Curcumin from the rhizome of Curcuma longa (zingiberaceae) has been reported to be a chemopreventive agent that affects cell proliferation by arresting the cell cycle in G2 and modulating the wnt signaling pathway. We found that curcumin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma (HCC) cells in a concentration-dependent manner. We identified that curcumin interrupts wnt signaling by decreasing -catenin activity, which in turn suppresses the expression of -catenin target genes (c-myc, VEGF and cyclin D1). Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional -catenin destruction complex in normal cells. This results in -catenin being unable to accumulate in the nucleus, depriving the protein of its ability to bind with lymphoid enhancer factor/T cell-specific transcription factor (Lef/Tcf) and repressing its activation of target gene transcription. This may be one mechanism through which curcumin inhibits proliferation and induces apoptosis of HCC cells.
资助项目	Tianjin Science and Technology Committee[11zckfsy07300]
WOS关键词	BETA-CATENIN ; CANCER ; TARGET ; ACTIVATION ; DISEASE
WOS研究方向	Oncology
语种	英语
出版者	SPANDIDOS PUBL LTD
WOS记录号	WOS:000330225800025
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277342]
专题	药物制剂研究中心
通讯作者	Xu, Marvin Xuejun
作者单位	1.Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 2012203, Peoples R China; 3.Henan Univ, Huaihe Hosp, Kaifeng 475000, Peoples R China; 4.Shanghai McAry Biomed Technol Co Ltd, Shanghai 201203, Peoples R China; 5.Zhengzhou Univ, Dept Pharmacol, Basic Med Coll, Zhengzhou 450001, Peoples R China;
推荐引用方式 GB/T 7714	Xu, Marvin Xuejun,Zhao, Linlin,Deng, Chaoyang,et al. Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2013,43(6):1951-1959.
APA	Xu, Marvin Xuejun.,Zhao, Linlin.,Deng, Chaoyang.,Yang, Lu.,Wang, Yang.,...&Zhang, Lirong.(2013).Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway.INTERNATIONAL JOURNAL OF ONCOLOGY,43(6),1951-1959.
MLA	Xu, Marvin Xuejun,et al."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway".INTERNATIONAL JOURNAL OF ONCOLOGY 43.6(2013):1951-1959.