Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine

doi:10.1021/ja508721y

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine
	Chen, Yu 1,3,4; Meng, Qingshuo 2; Wu, Meiying 1; Wang, Shige 1; Xu, Pengfei 2; Chen, Hangrong 1; Li, Yaping2 ; Zhang, Lingxia 1; Wang, Lianzhou 3,4; Shi, Jianlin 1
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2014-11-19
卷号	136 期号:46 页码:16326-16334
ISSN号	0002-7863
DOI	10.1021/ja508721y
文献子类	Article
英文摘要	Chemical construction of molecularly organic inorganic hybrid hollow mesoporous organosilica nano-particles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, and versatile chemical homology principle to synthesize multiple-hybridized HMONs with varied functional organic groups homogeneously incorporated into the framework (up to quintuple hybridizations). As a paradigm, the hybridization of physiologically active thioether groups with triple distinctive disulfide bonds can endow HMONs with unique intrinsic reducing/acidic- and external high intensity focused ultrasound (HIFU)-responsive drug-releasing performances, improved biological effects (e.g., lowered hemolytic effect and improved histocompatibility), and enhanced ultrasonography behavior. The doxorubicin-loaded HMONs with concurrent thioether and phenylene hybridization exhibit drastically enhanced therapeutic efficiency against cancer growth and metastasis, as demonstrated both in vitro and in vivo.
资助项目	Australian Research Council[00000000] ; National Nature Science Foundation of China[51302293] ; National Nature Science Foundation of China[51132009] ; National Nature Science Foundation of China[81230029] ; Shanghai Rising-Star Program[14QA1404100] ; Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures[SKL201203]
WOS关键词	SILICA NANOPARTICLES ; DRUG-DELIVERY ; TOPOLOGICAL TRANSFORMATION ; SYNERGISTIC THERAPY ; GOLD NANOSHELLS ; SHELL ; RELEASE ; CORE ; SIZE ; BIODISTRIBUTION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000345308700031
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276829]
专题	药物制剂研究中心
通讯作者	Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Queensland, Sch Chem Engn, Nanomat Ctr, Brisbane, Qld 4072, Australia; 4.Univ Queensland, Australia Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia;
推荐引用方式 GB/T 7714	Chen, Yu,Meng, Qingshuo,Wu, Meiying,et al. Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2014,136(46):16326-16334.
APA	Chen, Yu.,Meng, Qingshuo.,Wu, Meiying.,Wang, Shige.,Xu, Pengfei.,...&Shi, Jianlin.(2014).Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,136(46),16326-16334.
MLA	Chen, Yu,et al."Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 136.46(2014):16326-16334.