Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors

doi:10.1016/j.addr.2014.10.031

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors
	Wang, Huiyuan2 ; Jiang, Yifan 2; Peng, Huige 2; Chen, Yingzhi 2; Zhu, Peizhi 1; Huang, Yongzhuo2
刊名	ADVANCED DRUG DELIVERY REVIEWS
	2015-01
卷号	81 页码:142-160
关键词	MicroRNA Drug delivery Non-viral vector Synthetic vector Cancer therapy
ISSN号	0169-409X
DOI	10.1016/j.addr.2014.10.031
文献子类	Review
英文摘要	MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Because of significant changes in their expression in cancer, miRNAs are believed to be key factors in cancer genetics and to have potential as anticancer drugs. However, the delivery of miRNAs is limited by many barriers, such as low cellular uptake, immunogenicity, renal clearance, degradation by nucleases, elimination by phagocytic immune cells, poor endosomal release, and untoward side effects. Nonviral delivery systems have been developed to overcome these obstacles. In this review, we provide insights into the development of non-viral synthetic miRNA vectors and the promise of miRNA-based anticancer therapies, including therapeutic applications of miRNAs, challenges of vector design to overcome the delivery obstacles, and the development of miRNA delivery systems for cancer therapy. Additionally, we highlight some representative examples that give a glimpse into the current trends into the design and application of efficient synthetic systems for miRNA delivery. Overall, a better understanding of the rational design of miRNA delivery systems will promote their translation into effective clinical treatments. (C) 2014 Elsevier B.V. All rights reserved.
资助项目	National Basic Research Program of China (973 Program)[2014CB931902] ; National Basic Research Program of China (973 Program)[2013CB932503] ; NSFC, China[81172996] ; NSFC, China[81373357] ; NSFC, China[81422048] ; NSFC, China[81402883] ; Chinese Postdoctoral Science Foundation[2012M510097] ; Chinese Postdoctoral Science Foundation[2013T60478]
WOS关键词	SMALL INTERFERING RNA ; MOLECULAR-WEIGHT POLYETHYLENIMINE ; NANOPARTICLE-MEDIATED DELIVERY ; SHORT BRANCH PEI ; GENE DELIVERY ; IN-VIVO ; LUNG-CANCER ; REPLACEMENT THERAPY ; TARGETED DELIVERY ; SYSTEMIC DELIVERY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000348621600012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276759]
专题	药物制剂研究中心
通讯作者	Huang, Yongzhuo
作者单位	1.Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225009, Jiangsu, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wang, Huiyuan,Jiang, Yifan,Peng, Huige,et al. Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors[J]. ADVANCED DRUG DELIVERY REVIEWS,2015,81:142-160.
APA	Wang, Huiyuan,Jiang, Yifan,Peng, Huige,Chen, Yingzhi,Zhu, Peizhi,&Huang, Yongzhuo.(2015).Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors.ADVANCED DRUG DELIVERY REVIEWS,81,142-160.
MLA	Wang, Huiyuan,et al."Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors".ADVANCED DRUG DELIVERY REVIEWS 81(2015):142-160.