Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells

doi:10.1039/c5ra03083h

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells
	Liang, Jianming 1,2; Zeng, Feng 1,2; Zhang, Meng 1; Pan, Zhenzhen 1,3; Chen, Yingzhi 1; Zeng, Yuaner 3; Xu, Yong 4; Xu, Qin 2; Huang, Yongzhuo1
刊名	RSC ADVANCES
	2015
卷号	5 期号:54 页码:43733-43740
ISSN号	2046-2069
DOI	10.1039/c5ra03083h
文献子类	Article
英文摘要	The potent antitumor activities of silver nanoparticles (AgNP) have attracted great attention. However, the application of AgNP is restricted by its non-specific delivery and poor cellular uptake. We developed a novel hyaluronic acid (HA)-based strategy for the green synthesis of AgNP, in which HA was used as the reducing agent and stabilizer. More importantly, HA is a ligand of CD44, and the HA-modified AgNP can target CD44 receptors that are overexpressed in many types of cancer cells. The CD44-dependent endocytosis can significantly increase the intracellular delivery of HA-AgNP, compared to the non-modified one. The antitumor efficacy was significantly improved by HA modification. Furthermore, we found that multiple mechanisms were involved for the enhanced anticancer activities of HA-AgNP, including the decline of mitochondrial membrane potential, cell-cycle arrest, apoptosis, and autophagy. The HA-based strategy for green synthesis and CD44-targeting delivery provided a promising solution for AgNP-mediated cancer treatment.
资助项目	973 Program, China[2014CB931900] ; 973 Program, China[2013CB932503] ; NSFC, China[81172996] ; NSFC, China[81373357] ; NSFC, China[81422048]
WOS关键词	COLORECTAL-CANCER ; IN-VIVO ; APOPTOSIS ; EXPRESSION ; AUTOPHAGY ; MONODANSYLCADAVERINE ; PHOSPHATIDYLSERINE ; INHIBITION ; RESISTANCE ; RELEASE
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000354964600080
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276729]
专题	药物制剂研究中心
通讯作者	Huang, Yongzhuo
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 501450, Guangdong, Peoples R China; 3.Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 501450, Guangdong, Peoples R China; 4.Hubei Biol Med Ind Technol Inst Co Ltd, Wuhan 430075, Peoples R China
推荐引用方式 GB/T 7714	Liang, Jianming,Zeng, Feng,Zhang, Meng,et al. Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells[J]. RSC ADVANCES,2015,5(54):43733-43740.
APA	Liang, Jianming.,Zeng, Feng.,Zhang, Meng.,Pan, Zhenzhen.,Chen, Yingzhi.,...&Huang, Yongzhuo.(2015).Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells.RSC ADVANCES,5(54),43733-43740.
MLA	Liang, Jianming,et al."Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells".RSC ADVANCES 5.54(2015):43733-43740.