Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism

doi:10.2174/138920021603150812121453

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism
	Zhu, Quanlei 1,2; Li, Xiuying 1,2; Xia, Dengning 1; Yu, Hongzhen 1,2; Chen, Dan 1,2; Fan, Weiwei 1,2; Gan, Yong1
刊名	CURRENT DRUG METABOLISM
	2015
卷号	16 期号:3 页码:200-210
关键词	Absorption lipid formulations metabolism poorly soluble drug systemic exposure
ISSN号	1389-2002
DOI	10.2174/138920021603150812121453
文献子类	Article
英文摘要	The application of lipid-based drug delivery systems on the industrial scale has successfully demonstrated their therapeutic and manufacturing advantages. Recently, various lipid-based formulations were successfully prepared for oral delivery of compounds that are difficult to administer. Nevertheless, an improved understanding of how these formulations affect drug absorption and metabolism is required to support the rapid and successful completion of drug development programs. In this review, we report the detailed mechanisms whereby lipids and lipid-based excipients affect drug absorption and metabolism, and summarize the capacity of lipids and lipid-based formulations to improve drug absorption by improving drug solubility, mucosa penetration, lymphatic transport, and hepatic metabolism. Finally, we discuss the progress made toward the use of novel lipid formulations to enhance oral absorption by surmounting specific absorption barriers.
资助项目	National Natural Science Foundations of China[81373356] ; "Science and technology innovation action plan for basic research" of Shanghai[14JC1493200] ; National Natural Science Foundation of China[81202468]
WOS关键词	IN-VITRO DIGESTION ; INTESTINAL LYMPHATIC TRANSPORT ; POORLY SOLUBLE DRUGS ; P-GLYCOPROTEIN ; LIPOPHILIC DRUGS ; POLYMERIC NANOPARTICLES ; MUCOADHESIVE PROPERTIES ; COATED LIPOSOMES ; CELLULAR UPTAKE ; BIOAVAILABILITY
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000359604700003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276716]
专题	药物制剂研究中心
通讯作者	Gan, Yong
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Quanlei,Li, Xiuying,Xia, Dengning,et al. Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism[J]. CURRENT DRUG METABOLISM,2015,16(3):200-210.
APA	Zhu, Quanlei.,Li, Xiuying.,Xia, Dengning.,Yu, Hongzhen.,Chen, Dan.,...&Gan, Yong.(2015).Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism.CURRENT DRUG METABOLISM,16(3),200-210.
MLA	Zhu, Quanlei,et al."Lipid-Based Formulations for Oral Drug Delivery: Effects on Drug Absorption and Metabolism".CURRENT DRUG METABOLISM 16.3(2015):200-210.