Advances in the transepithelial transport of nanoparticles

doi:10.1016/j.drudis.2016.05.007

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Advances in the transepithelial transport of nanoparticles
	Yu, Miaorong 1,2; Yang, Yiwei 1,2; Zhu, Chunliu2 ; Guo, Shiyan 2; Gan, Yong1,2
刊名	DRUG DISCOVERY TODAY
	2016-07
卷号	21 期号:7 页码:1155-1161
ISSN号	1359-6446
DOI	10.1016/j.drudis.2016.05.007
文献子类	Review
英文摘要	The intestinal epithelium represents a barrier to the delivery of nanoparticles (NPs). It prevents intact NPs from efficiently crossing the mucosa to access the circulation, thus limiting the successful application of NP-based oral drug delivery. Recent advances in nanotechnology have provided promising solutions to this challenge. This review describes the potential intestinal absorption pathways of NPs, including the transenterocytic pathway, paracellular pathway and M-cell-mediated pathway. NP properties that influence transcytosis are summarized; and the biodistribution of NPs after oral absorption is described and the future prospects of novel NPs are explored.
资助项目	National Natural Science Foundation of China[81373356] ; National Natural Science Foundation of China[81573378] ; Science and Technology Innovation Action Plan for Basic Research of Shanghai[14JC1493200] ; [CASIMM0120153020]
WOS关键词	CELL-HOMING PEPTIDE ; SOLID LIPID NANOPARTICLES ; ORAL-DRUG DELIVERY ; PARTICLE-SIZE ; EPITHELIAL-CELLS ; CHITOSAN NANOPARTICLES ; PENETRATING PEPTIDES ; SILICA NANOPARTICLES ; PAMAM DENDRIMERS ; ABSORPTION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000379105000011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275975]
专题	药物制剂研究中心
通讯作者	Gan, Yong
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Yu, Miaorong,Yang, Yiwei,Zhu, Chunliu,et al. Advances in the transepithelial transport of nanoparticles[J]. DRUG DISCOVERY TODAY,2016,21(7):1155-1161.
APA	Yu, Miaorong,Yang, Yiwei,Zhu, Chunliu,Guo, Shiyan,&Gan, Yong.(2016).Advances in the transepithelial transport of nanoparticles.DRUG DISCOVERY TODAY,21(7),1155-1161.
MLA	Yu, Miaorong,et al."Advances in the transepithelial transport of nanoparticles".DRUG DISCOVERY TODAY 21.7(2016):1155-1161.