Advances in the transepithelial transport of nanoparticles | |
Yu, Miaorong1,2; Yang, Yiwei1,2; Zhu, Chunliu2![]() ![]() | |
刊名 | DRUG DISCOVERY TODAY
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2016-07 | |
卷号 | 21期号:7页码:1155-1161 |
ISSN号 | 1359-6446 |
DOI | 10.1016/j.drudis.2016.05.007 |
文献子类 | Review |
英文摘要 | The intestinal epithelium represents a barrier to the delivery of nanoparticles (NPs). It prevents intact NPs from efficiently crossing the mucosa to access the circulation, thus limiting the successful application of NP-based oral drug delivery. Recent advances in nanotechnology have provided promising solutions to this challenge. This review describes the potential intestinal absorption pathways of NPs, including the transenterocytic pathway, paracellular pathway and M-cell-mediated pathway. NP properties that influence transcytosis are summarized; and the biodistribution of NPs after oral absorption is described and the future prospects of novel NPs are explored. |
资助项目 | National Natural Science Foundation of China[81373356] ; National Natural Science Foundation of China[81573378] ; Science and Technology Innovation Action Plan for Basic Research of Shanghai[14JC1493200] ; [CASIMM0120153020] |
WOS关键词 | CELL-HOMING PEPTIDE ; SOLID LIPID NANOPARTICLES ; ORAL-DRUG DELIVERY ; PARTICLE-SIZE ; EPITHELIAL-CELLS ; CHITOSAN NANOPARTICLES ; PENETRATING PEPTIDES ; SILICA NANOPARTICLES ; PAMAM DENDRIMERS ; ABSORPTION |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000379105000011 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/275975] ![]() |
专题 | 药物制剂研究中心 |
通讯作者 | Gan, Yong |
作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China; |
推荐引用方式 GB/T 7714 | Yu, Miaorong,Yang, Yiwei,Zhu, Chunliu,et al. Advances in the transepithelial transport of nanoparticles[J]. DRUG DISCOVERY TODAY,2016,21(7):1155-1161. |
APA | Yu, Miaorong,Yang, Yiwei,Zhu, Chunliu,Guo, Shiyan,&Gan, Yong.(2016).Advances in the transepithelial transport of nanoparticles.DRUG DISCOVERY TODAY,21(7),1155-1161. |
MLA | Yu, Miaorong,et al."Advances in the transepithelial transport of nanoparticles".DRUG DISCOVERY TODAY 21.7(2016):1155-1161. |
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