Spray drying of fenofibrate loaded nanostructured lipid carriers

doi:10.1016/j.ajps.2016.01.001

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	Spray drying of fenofibrate loaded nanostructured lipid carriers
	Xia, Dengning 2,3; Shrestha, Neha 2; van de Streek, Jacco 2; Mu, Huiling 2; Yang, Mingshi 1,2,4
刊名	ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2016-08
卷号	11 期号:4 页码:507-515
关键词	Fenofibrate Nanostructured lipid carriers Spray drying Design of experiments Central composite face-centered design
ISSN号	1818-0876
DOI	10.1016/j.ajps.2016.01.001
文献子类	Article
英文摘要	The conversion of aqueous dispersion of nanostructured lipid carriers (NLCs) into dry powder by spray drying could be a useful approach to render NLCs with better physical chemical stability than the aqueous dispersion. In this study, aqueous NLC dispersion containing fenofibrate was converted into dry, easily reconstitutable powder using spray drying. A central composite face centered design (CCFD) was used to investigate the influence of the ratio of lipid to protectant (mannitol and trehalose) and crystallinity of spray-dried powder on the particle size, yield and residual moisture content of the dried powder. A linear relationship (R-2 = 0.9915) was established between the crystalline content of the spray-dried powders against the ratio of mannitol to trehalose from 3: 7 to 10: 0 (w/w). Spray drying of NLC aqueous dispersion using a mannitol and trehalose mixture resulted in an increase in particle size of the NLCs after reconstitution in water as compared to that in the initial aqueous dispersion. The decrease in crystallinity of the dry powder by reducing the ratio of mannitol to trehalose could improve the reconstitution of the NLCs in water. However the yield and residual moisture content of dry powder decreased with an increase in the ratio of mannitol to trehalose. Lipid nanoparticles were able to retain the drug incorporation and the prolonged drug release profile after spray drying. The experimental model was robust, and suggested that spray drying is a viable technique for the conversion of NLCs into dry powder. (C) 2016 Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. This is an open access article under the CC BY-NC-ND license
资助项目	Lundbeck Foundation (Denmark)[R49-A5604] ; National Nature Science Foundation of China[81573380]
WOS关键词	NANOPARTICLES SLN ; NANOCOMPOSITE PARTICLES ; DESIGN APPROACH ; DRUG ; DELIVERY ; OPTIMIZATION ; FORMULATIONS ; MANNITOL ; RELEASE ; POLYMORPHISM
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	HONG KONG ASIAMED PUBLISH HOUSE
WOS记录号	WOS:000384282900007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275934]
专题	药物制剂研究中心
通讯作者	Yang, Mingshi
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Peoples R China; 2.Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Fudan Univ, Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xia, Dengning,Shrestha, Neha,van de Streek, Jacco,et al. Spray drying of fenofibrate loaded nanostructured lipid carriers[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,11(4):507-515.
APA	Xia, Dengning,Shrestha, Neha,van de Streek, Jacco,Mu, Huiling,&Yang, Mingshi.(2016).Spray drying of fenofibrate loaded nanostructured lipid carriers.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,11(4),507-515.
MLA	Xia, Dengning,et al."Spray drying of fenofibrate loaded nanostructured lipid carriers".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 11.4(2016):507-515.