Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects

doi:10.1248/bpb.24.662

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	Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects
	Li, YP; Pei, YY ; Zhou, ZH ; Zhang, XY ; Gu, ZH ; Ding, J; Zhou, JJ ; Gao, XJ ; Zhu, JH
刊名	BIOLOGICAL & PHARMACEUTICAL BULLETIN
	2001-06
卷号	24 期号:6 页码:662-665
关键词	poly(ethylene glycol) poly(alkyl cyanoacrylate) nanoparticle stealth poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) turner necrosis factor-alpha
ISSN号	0918-6158
DOI	10.1248/bpb.24.662
文献子类	Article
英文摘要	The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-a (rHuTNF-alpha) encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles, Our experimental results showed that PEG-PHDCA nanoparticles could extend the half-life of rHuTNF-alpha to 7.42 h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-alpha in tumor. Compared with PHDCA nanoparticles and free rHuTNF-alpha PEG-PHDCA nanoparticles loaded with rHuTNF-alpha showed higher antitumor potency at the same dose, which might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoparticles could be an effective carrier for rHuTNF-alpha.
WOS关键词	AMPHIPHILIC COPOLYMER ; CIRCULATION TIME ; TNF-ALPHA ; NANOSPHERES ; LIPOSOMES ; SARCOMA ; RATS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	PHARMACEUTICAL SOC JAPAN
WOS记录号	WOS:000169026200013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274487]
专题	药物制剂研究中心
通讯作者	Li, YP
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 200031, Peoples R China 2.Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Li, YP,Pei, YY,Zhou, ZH,et al. Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2001,24(6):662-665.
APA	Li, YP.,Pei, YY.,Zhou, ZH.,Zhang, XY.,Gu, ZH.,...&Zhu, JH.(2001).Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects.BIOLOGICAL & PHARMACEUTICAL BULLETIN,24(6),662-665.
MLA	Li, YP,et al."Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: Pharmacokinetics and anti-tumor effects".BIOLOGICAL & PHARMACEUTICAL BULLETIN 24.6(2001):662-665.