H-II mesophase as a drug delivery system for topical application of methyl salicylate

doi:10.1016/j.ejps.2016.12.033

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	H-II mesophase as a drug delivery system for topical application of methyl salicylate
	Liang, Xin 2; Chen, Yu-lin 2; Jiang, Xiao-jing 2; Wang, Sheng-mei 2; Zhang, Ji-wen3 ; Gui, Shuang-ying 1,2,4
刊名	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2017-03-30
卷号	100 页码:155-162
关键词	H-II mesophase Liquid crystalline Methyl salicylate Transdermal delivery
ISSN号	0928-0987
DOI	10.1016/j.ejps.2016.12.033
文献子类	Article
英文摘要	The main objective of this study was to develop reversed hexagonal (H-II) mesophase for transdermal delivery of methyl salicylate. The formulation was prepared, characterized and evaluated for its skin penetration in vitro and skin retention in vivo. Preliminary pharmacodynamics and skin irritation were also investigated. The formulation was identified as hexagonal structure. In vitro study exhibited that H-II mesophase enhanced the skin permeation by delivering 2.61 times more methyl salicylate than the commercially available cream. Meanwhile, H-II mesophase presented higher bioavailability as AUC((0-24)) and AUC((0-infinity)) were 32.894 mu g.mL(-1) and 32.935 mu g.mL(-1) respectively, while the cream were 12.791 mu g.mL(-1) and 12.970 mu g.ml(-1). Preliminary pharmacodynamics studies demonstrated that H-II mesophase possessed anti-inflammatory and analgesic effects for inhibiting paw edema, granuloma and pain. MeSa H-II mesophase showed no skin irritation on the normal rat skin. Thus, H-II mesophase was considered as an effective delivery system for MeSa. (C) 2016 Published by Elsevier B.V.
资助项目	National Natural Science Foundation of China[81274099]
WOS关键词	REVERSE HEXAGONAL MESOPHASES ; PHASE-BEHAVIOR ; CYCLOSPORINE-A ; IN-VITRO ; NANOSTRUCTURE ; MONOOLEIN ; GELS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000397373900018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272734]
专题	药物制剂研究中心
通讯作者	Gui, Shuang-ying
作者单位	1.Key Lab Xinan Med, Minist Educ, Hefei 230012, Anhui, Peoples R China 2.Anhui Univ Chinese Med, Dept Pharm, 1,Qianjiang Rd, Hefei 230012, Anhui, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Medico, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 4.Anhui Acad Chinese Med, Inst Pharmaceut, Hefei 230012, Anhui, Peoples R China;
推荐引用方式 GB/T 7714	Liang, Xin,Chen, Yu-lin,Jiang, Xiao-jing,et al. H-II mesophase as a drug delivery system for topical application of methyl salicylate[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,100:155-162.
APA	Liang, Xin,Chen, Yu-lin,Jiang, Xiao-jing,Wang, Sheng-mei,Zhang, Ji-wen,&Gui, Shuang-ying.(2017).H-II mesophase as a drug delivery system for topical application of methyl salicylate.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,100,155-162.
MLA	Liang, Xin,et al."H-II mesophase as a drug delivery system for topical application of methyl salicylate".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 100(2017):155-162.