A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide

doi:10.1021/acs.langmuir.7b00189

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	A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide
	Feng, Chongchong 1; Wang, Fengyang 1; Dang, Yijing 1; Xu, Zhiai 1; Yu, Haijun2 ; Zhang, Wen 1
刊名	LANGMUIR
	2017-04-04
卷号	33 期号:13 页码:3287-3295
ISSN号	0743-7463
DOI	10.1021/acs.langmuir.7b00189
文献子类	Article
英文摘要	In this study, a dual-emission fluorescence resonance energy transfer (FRET) polymeric nanoprobe by single wavelength excitation was developed for sensitive and selective hydrogen peroxide (H2O2) detection. Polymeric nanoprobe was prepared by simple self-assembly Of functional lipopolymers, which were 4-carboxy-3-fluorophenylboronic acid (FPBA)-modified DSPE-PEG (DSPE-PEG-FPBA) and 7-hydroxycoumarin :(HC)-conjugated DSPE-PEG (DSPE-PEG-HC). Subsequent binding of alizarin red S (ARS) to FPBA endowed the nanoprobe with a new fluorescence emission peak at around 600 nm. Because of the perfect match of the fluorescence emission spectra of HC with the absorbance spectra of ARS-FPBA, FRET was achieved between them. The sensing strategy for H2O2 was based on H2O2-induced deboronadon reaction and boronic acid-mediated ARS fluorescence. Interaction between phenylboronic acid and ARS was revisited herein and it was found that electron-donating or-withdrawing group on phenylboronic acid (PBA) has significant influence.on the fluorescence property of ARS, which enabled sensitive and selective H2O2 sensing. The nanoprobe displayed two well-separated emission bands (150 nm), providing high specificity and sensitivity for ratiometric detection of H2O2. Further application was exploited for the determination of glucose and the results demonstrated that the proposed strategy showed ratiometric response capability for glucose detection. The current method does not involve complicated organic synthesis and opens a new avenue for the construction of multifunctional polymeric fluorescent nanoprobe.
资助项目	National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[21375040] ; National Natural Science Foundation of China[21635003]
WOS关键词	BLOCK-COPOLYMER MICELLES ; PHENYLBORONIC ACID ; GOLD NANOCLUSTERS ; LIVING CELLS ; BORONIC ACID ; GLUCOSE ; PROBE ; DELIVERY ; NANOPARTICLES ; NANOCARRIERS
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000398646200015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272707]
专题	药物制剂研究中心
通讯作者	Xu, Zhiai
作者单位	1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Feng, Chongchong,Wang, Fengyang,Dang, Yijing,et al. A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide[J]. LANGMUIR,2017,33(13):3287-3295.
APA	Feng, Chongchong,Wang, Fengyang,Dang, Yijing,Xu, Zhiai,Yu, Haijun,&Zhang, Wen.(2017).A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide.LANGMUIR,33(13),3287-3295.
MLA	Feng, Chongchong,et al."A Self-Assembled Ratiometric Polymeric Nanoprobe for Highly Selective Fluorescence Detection of Hydrogen Peroxide".LANGMUIR 33.13(2017):3287-3295.