Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks

doi:10.1080/02652048.2018.1462417

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks
	Zhang, Guoqing 2,3,5; Meng, Fanyue 2,5; Guo, Zhen 1,2; Guo, Tao 2; Peng, Hui 4; Xiao, Jian 4; Liu, Botao 2; Singh, Vikaramjeet 2; Gui, Shuangying 5; York, Peter 1
刊名	JOURNAL OF MICROENCAPSULATION
	2018
卷号	35 期号:3 页码:249-258
关键词	gamma-Cyclodextrin metal-organic frameworks vitamin A stability microencapsulation
ISSN号	0265-2048
DOI	10.1080/02652048.2018.1462417
文献子类	Article
英文摘要	gamma-Cyclodextrin metal-organic frameworks (gamma-CD-MOFs) are highly porous and bio-friendly novel materials formed by gamma-CD as an organic ligand and potassium ion as an inorganic metal centre. The aim of this study was to enhance the stability of vitamin A palmitate (VAP) using y-CDMOFs as the carrier. Herein, gamma-CD-MOFs displayed VAP microencapsulating capacity of 9.77 +/- 0.24% with molar ratio as n(MOFs) : n(VAP) = 3.2:1.0. It was important to find that the improved stability of VAP microencapsulated by y-CD-MOFs without addition of any antioxidant(s) was better than that of the best available reference product in the market, with 1.6-fold elongated half-life. The protecting mechanism of gamma-CD-MOFs for VAP contributed that VAP molecules preferentially curled inside the cavities of dual gamma-CD pairs in gamma-CD-MOFs. It was proved that gamma-CDMOFs were an efficient new carrier to deliver and protect VAP for food and pharmaceutical applications.
WOS关键词	FORTIFIED SOYBEAN OIL ; DRUG-DELIVERY ; PARTICLES ; BINDING ; MILK
WOS研究方向	Chemistry ; Engineering ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000440363100004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272305]
专题	药物制剂研究中心
通讯作者	Wu, Li; Zhang, Jiwen
作者单位	1.Univ Bradford, Inst Pharmaceut Innovat, Bradford, W Yorkshire, England; 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Materia Med, Shanghai 201203, Peoples R China; 3.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai, Peoples R China; 4.By Hlth Co Ltd, Sci & Technol Ctr, Guangzhou, Guangdong, Peoples R China 5.Anhui Univ Chinese Med, Sch Pharmaceut Sci, Hefei, Anhui, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, Guoqing,Meng, Fanyue,Guo, Zhen,et al. Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks[J]. JOURNAL OF MICROENCAPSULATION,2018,35(3):249-258.
APA	Zhang, Guoqing.,Meng, Fanyue.,Guo, Zhen.,Guo, Tao.,Peng, Hui.,...&Zhang, Jiwen.(2018).Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks.JOURNAL OF MICROENCAPSULATION,35(3),249-258.
MLA	Zhang, Guoqing,et al."Enhanced stability of vitamin A palmitate microencapsulated by gamma-cyclodextrin metal-organic frameworks".JOURNAL OF MICROENCAPSULATION 35.3(2018):249-258.