Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery
	Li Meiyun 1; Liu Jinfen 1; Zhao Yanan 2; Chen Xi 2; Gan Yong2 ; Guo Shiyan 2; Li Daning 1
刊名	Chinese Journal of New Drugs and Clinical Remedies
	2014
卷号	33 期号:9 页码:683-688
关键词	tranexamic acid nanostructures administration, cutaneous transdermal effect nano - cream
ISSN号	1007-7669
其他题名	氨甲环酸纳米乳膏的制备及体外透皮效果评价
文献子类	Article
英文摘要	AIM To prepare tranexamic acid nano-cream (TA-NC) and evaluate the transdermal effect of TA-NC in vitro. METHODS TA-NC was prepared by further process from TA nano - emulsion which was got through high pressure homogenizing method. TA - NC was characterized for the particle size,morphology and encapsulation efficiency. The transdermal effect of the nano-cream was evaluated by in vitro transdermal delivery/ permeation experiments by using skin of nude mice as model. And the TA - NC labeled with Nile red was prepared to study the improved absorption behavior into the dermis of TA by confocal assay in skin of nude mice,too. Accelerated stability test was also carried out for 6 months. RESULTS The prepared TA - NC was (109.9 7.4) nm and presented a regular spherical surface with homogeneous distribution. The encapsulation efficiency was (90.13 2.90) %. In vitro transdermal absorption experiment showed that the retention of TA in skin was saturated after 6 h administration in the TA - NC group,and the total permeated amount of TA was (163.9 7.4) mug · cm~(-2), whereas the amount of TA solution group was ( 15.9 0.8) mug · cm~(-2), with a significant difference (P < 0.01) . Comparing with Nile red - TA solution which observed fluorescent only in cuticle, the Nile red labeled TA-NC was observed to permeate the cuticle and epidermis and reach the dermis by confocal assay,and the smaller the particle size of TA-NC, the stronger the ability of transdermal ability. The samples showed no significant differences in external properties, related substance, contents and particle size after accelerated stability test. CONCLUSION The TA-NC preparation technology is simple, and the TANC is good stability and can improve the transdermal absorption of TA significantly.
资助项目	上海市卫生局青年科研项目[00000000] ; 中国科学院上海药物研究所临床研究中心科研项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5250551
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269313]
专题	药物制剂研究中心
作者单位	1.Department of Dermatology, Central Hospital of Shanghai Xuhui District, SHANGHAI 200031, China.; 2.Center for Drug Delivery System, Shanghai Institute of Materia Medica Chinese Academy of Sciences, SHANGHAI 201203, China.
推荐引用方式 GB/T 7714	Li Meiyun,Liu Jinfen,Zhao Yanan,et al. Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery[J]. Chinese Journal of New Drugs and Clinical Remedies,2014,33(9):683-688.
APA	Li Meiyun.,Liu Jinfen.,Zhao Yanan.,Chen Xi.,Gan Yong.,...&Li Daning.(2014).Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery.Chinese Journal of New Drugs and Clinical Remedies,33(9),683-688.
MLA	Li Meiyun,et al."Preparation and in vitro evaluation of tranexamic acid nano - cream for transdermal delivery".Chinese Journal of New Drugs and Clinical Remedies 33.9(2014):683-688.