Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity

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	Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity
	Zhang Tao 2; Zhang Xinxin1 ; Gan Yong1 ; Wu Na 1; Zhu Jingjing 1; He Shufang 1; Liu Hui 2
刊名	Acta Pharmaceutica Sinica
	2015
卷号	50 期号:5 页码:605-612
关键词	polymyxin E PEGylation bacterial infection nephrotoxicity
ISSN号	0513-4870
其他题名	聚乙二醇化多粘菌素E对革兰阴性菌感染的治疗效果及降低肾毒性的作用
文献子类	Article
英文摘要	Polymyxin E shows effective treatment of the infection induced by resistant gramnegative bacteria, but its nephrotoxicity severely limits the clinical application of this drug. In this work, methoxypolyethylene glycols 2000 (mPEG2K)-polymyxin E (PME) was synthesized via chemical grafting reaction and had been characterized. The antimicrobial activity and cytotoxicity of mPEG2K-PME in vitro were investigated on Escherichia coli and HK-2 cells, separately. Intra-abdominal infection model was further established in order to study the therapeutic effect and the toxic effect on kidney of mice. The results showed that mPEG2K-PME exhibited significant inhibitory effect on Escherichia coli and had a lower toxicity on HK-2 cells in vitro.At the same time, mPEG2K-PME had a good efficacy in the treatment of Escherichia coli infected mice in vivo. Moreover, nephrotoxicity caused by mPEG2K-PME was significantly reduced compared to free PME. mPEG2K-PME is promising in development of new preparations with high efficiency and low toxicity.
资助项目	上海市科委产学研医资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5410806
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269285]
专题	药物制剂研究中心
作者单位	1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, China.;
推荐引用方式 GB/T 7714	Zhang Tao,Zhang Xinxin,Gan Yong,et al. Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity[J]. Acta Pharmaceutica Sinica,2015,50(5):605-612.
APA	Zhang Tao.,Zhang Xinxin.,Gan Yong.,Wu Na.,Zhu Jingjing.,...&Liu Hui.(2015).Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity.Acta Pharmaceutica Sinica,50(5),605-612.
MLA	Zhang Tao,et al."Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity".Acta Pharmaceutica Sinica 50.5(2015):605-612.