Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity | |
Zhang Tao2; Zhang Xinxin1![]() ![]() | |
刊名 | Acta Pharmaceutica Sinica
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2015 | |
卷号 | 50期号:5页码:605-612 |
关键词 | polymyxin E PEGylation bacterial infection nephrotoxicity |
ISSN号 | 0513-4870 |
其他题名 | 聚乙二醇化多粘菌素E对革兰阴性菌感染的治疗效果及降低肾毒性的作用 |
文献子类 | Article |
英文摘要 | Polymyxin E shows effective treatment of the infection induced by resistant gramnegative bacteria, but its nephrotoxicity severely limits the clinical application of this drug. In this work, methoxypolyethylene glycols 2000 (mPEG2K)-polymyxin E (PME) was synthesized via chemical grafting reaction and had been characterized. The antimicrobial activity and cytotoxicity of mPEG2K-PME in vitro were investigated on Escherichia coli and HK-2 cells, separately. Intra-abdominal infection model was further established in order to study the therapeutic effect and the toxic effect on kidney of mice. The results showed that mPEG2K-PME exhibited significant inhibitory effect on Escherichia coli and had a lower toxicity on HK-2 cells in vitro.At the same time, mPEG2K-PME had a good efficacy in the treatment of Escherichia coli infected mice in vivo. Moreover, nephrotoxicity caused by mPEG2K-PME was significantly reduced compared to free PME. mPEG2K-PME is promising in development of new preparations with high efficiency and low toxicity. |
资助项目 | 上海市科委产学研医资助项目[00000000] |
WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:5410806 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/269285] ![]() |
专题 | 药物制剂研究中心 |
作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, China.; |
推荐引用方式 GB/T 7714 | Zhang Tao,Zhang Xinxin,Gan Yong,et al. Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity[J]. Acta Pharmaceutica Sinica,2015,50(5):605-612. |
APA | Zhang Tao.,Zhang Xinxin.,Gan Yong.,Wu Na.,Zhu Jingjing.,...&Liu Hui.(2015).Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity.Acta Pharmaceutica Sinica,50(5),605-612. |
MLA | Zhang Tao,et al."Therapeutic efficacy of pegylated polymyxin E in the treatment of infection induced by gramnegative bacteria and the effect of reducing nephrotoxicity".Acta Pharmaceutica Sinica 50.5(2015):605-612. |
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