Quantitative structure characteristics and fractal dimension of Chinese medicine granules measured by synchrotron radiation X-ray computed micro tomography

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	Quantitative structure characteristics and fractal dimension of Chinese medicine granules measured by synchrotron radiation X-ray computed micro tomography
	Lu Xiaolong 2; Zheng Qin 1; Yin Xianzhen 3; Xiao Guangqing 3; Liao Zuhua 3; Yang Ming 1; Zhang Jiwen2
刊名	Acta Pharmaceutica Sinica
	2015
卷号	50 期号:6 页码:767-774
关键词	granulation process synchrotron radiation X-ray computed micro tomography three-dimensional reconstruction fractal dimension
ISSN号	0513-4870
其他题名	同步辐射显微CT用于中药颗粒定量结构特征与分形维度的研究
文献子类	Article
英文摘要	The shape and structure of granules are controlled by the granulation process, which is one of the main factors to determine the nature of the solid dosage forms. In this article, three kinds of granules of a traditional Chinese medicine for improving appetite and promoting digestion, namely, Jianwei Granules, were prepared using granulation technologies as pendular granulation, high speed stirring granulation, and fluidized bed granulation and the powder properties of them were investigated. Meanwhile, synchrotron radiation X-ray computed micro tomography(SR-muCT)was applied to quantitatively determine the irregular internal structures of the granules. The three-dimensional(3D)structure models were obtained by 3D reconstruction, which were more accurately to characterize the three-dimensional structures of the particles through the quantitative data. The models were also used to quantitatively compare the structural differences of granules prepared by different granulation processes with the same formula, so as to characterize how the production process plays a role in the pharmaceutical behaviors of the granules. To focus on the irregularity of the particle structure, the box counting method was used to calculate the fractal dimensions of the granules. The results showed that the fractal dimension is more sensitive to reflect the minor differences in the structure features than the conventional parameters, and capable to specifically distinct granules in structure. It is proved that the fractal dimension could quantitatively characterize the structural information of irregular granules. It is the first time suggested by our research that the fractal dimension difference(Df,c)between two fractal dimension parameters, namely, the volume matrix fractal dimension and the surface matrix fractal dimension, is a new index to characterize granules with irregular structures and evaluate the effects of production processes on the structures of granules as a new indicator for the granulating process control and optimization.
资助项目	国家自然科学基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5442935
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269282]
专题	药物制剂研究中心分子影像中心（筹）
通讯作者	Zhang Jiwen
作者单位	1.Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, China.; 2.Shanghai Institute of Technology, Shanghai 201418, China.; 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Lu Xiaolong,Zheng Qin,Yin Xianzhen,et al. Quantitative structure characteristics and fractal dimension of Chinese medicine granules measured by synchrotron radiation X-ray computed micro tomography[J]. Acta Pharmaceutica Sinica,2015,50(6):767-774.
APA	Lu Xiaolong.,Zheng Qin.,Yin Xianzhen.,Xiao Guangqing.,Liao Zuhua.,...&Zhang Jiwen.(2015).Quantitative structure characteristics and fractal dimension of Chinese medicine granules measured by synchrotron radiation X-ray computed micro tomography.Acta Pharmaceutica Sinica,50(6),767-774.
MLA	Lu Xiaolong,et al."Quantitative structure characteristics and fractal dimension of Chinese medicine granules measured by synchrotron radiation X-ray computed micro tomography".Acta Pharmaceutica Sinica 50.6(2015):767-774.