Optimization and evaluation of a new antischistosomal drug  QH917 self-microemulsifying drug delivery system

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system
	ZHANG Jianyuan 2; GAN Yong1 ; GAN Li 1; ZHU Chunliu1 ; PAN Weisan 2
刊名	Acta Pharmaceutica Sinica
	2007
卷号	42 期号:4 页码:434-439
关键词	antischistosomal drug central composite design-response surface methodology selfmicroemulsifying drug delivery system in situ intestinal absorption
ISSN号	0513-4870
其他题名	新型抗血吸虫药物QH917自微乳化释药系统的优化和评价
文献子类	Article
英文摘要	To screen a new poorly water-soluble antischistosomal drug QH917 self-microemulsifying drug delivery system which has steady release in vitro and absorption in situ separately.The formulation was optimized using central composite design-response surface methodology.Independent variables were oil content(%) and the weight ratio of surfactant and cosurfactant(K_m),while response variables were self-microemulsifying time(t),mean particle size(PS) and polydispersity index(PI).The effects of ionic strength,food,pH,rotation speed and medium volume on drug release of the optimized formulation were evaluated under conditions simulating in vivo physiological situations.The absorption of the optimized formulation was studied using in situ intestinal permeability technique of rats.The optimized formulation was as follows: the content of media chain triglyceride(MCT) was 30%-34%(w/w);and the weight ratio of surfactant polyoxyl 40 hydrogenated castor oil(Cremophor RH40) and co-surfactant ethanol was 4.8-5.2.Release of QH917 from the optimized formulation was nearly unaffected by ionic strength,food,pH,rotation speed and medium volume.There was no marked difference of the absorption rate between rats with and without ligated bile duct in rat intestinal permeability technique.Inter-individual variability in absorption of the optimized formulation was negligible.Central composite design-response surface methodology is an efficient approach for optimizing formulations of self-microemulsifying drug delivery system;drug release in vitro and absorption behavior in situ of the optimized formulation is steady.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2877160
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268161]
专题	药物制剂研究中心
作者单位	1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. 2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.;
推荐引用方式 GB/T 7714	ZHANG Jianyuan,GAN Yong,GAN Li,et al. Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system[J]. Acta Pharmaceutica Sinica,2007,42(4):434-439.
APA	ZHANG Jianyuan,GAN Yong,GAN Li,ZHU Chunliu,&PAN Weisan.(2007).Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system.Acta Pharmaceutica Sinica,42(4),434-439.
MLA	ZHANG Jianyuan,et al."Optimization and evaluation of a new antischistosomal drug QH917 self-microemulsifying drug delivery system".Acta Pharmaceutica Sinica 42.4(2007):434-439.