Application of the dose-division method in the in vivo release kinetics evaluation of the sodium theophylline glycinate sustained release dosage forms

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	Application of the dose-division method in the in vivo release kinetics evaluation of the sodium theophylline glycinate sustained release dosage forms
	DING Wenzhong 2; ZHAO Jing2 ; ZhANG Jiwen2
刊名	The Chinese Journal of Clinical Pharmacology
	2007
卷号	23 期号:5 页码:376-379
关键词	dose division method sodium theophylline glycinate sustained release tablets pharmacokinetics in vivo release
ISSN号	1001-6821
其他题名	剂量分割法评价甘氨酸茶碱钠缓释片体内释放度及其体内外相关性
文献子类	Article
英文摘要	Objective To evaluate the in vivo release behavior and its correlation with the in vitro release profile of sodium theophylline glycinate sustained release tablets (STG-ST) by the dose-division method in comparison with the correlation of absorption and release kinetics by Wagner-Nelson method.Methods The in vivo release profile of STG-ST was processed based upon the principles of the dose-division method, while the absorption profiles were processed by Wagner-Nelson method using two eliminate rate constants. Results The direct application of the Wagner-Nelson method to the controlled/sustained release systems might lead to methodological mistakes by using the apparent eliminate rate constant of the controlled/sustained release systems. The in vivo release profile by dose-division method was well correlated with the in vitro release kinetics of STG-ST. Conclusion The dose-division method is a novel and effective way for the in vitro-in vivo correlation-ship evaluation with no requirement of the injection parameters.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2966090
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268110]
专题	药物制剂研究中心
通讯作者	ZhANG Jiwen
作者单位	1.Shanghai 201203, China. 2.Shanghai Institute of Materia Medica;
推荐引用方式 GB/T 7714	DING Wenzhong,ZHAO Jing,ZhANG Jiwen. Application of the dose-division method in the in vivo release kinetics evaluation of the sodium theophylline glycinate sustained release dosage forms[J]. The Chinese Journal of Clinical Pharmacology,2007,23(5):376-379.
APA	DING Wenzhong,ZHAO Jing,&ZhANG Jiwen.(2007).Application of the dose-division method in the in vivo release kinetics evaluation of the sodium theophylline glycinate sustained release dosage forms.The Chinese Journal of Clinical Pharmacology,23(5),376-379.
MLA	DING Wenzhong,et al."Application of the dose-division method in the in vivo release kinetics evaluation of the sodium theophylline glycinate sustained release dosage forms".The Chinese Journal of Clinical Pharmacology 23.5(2007):376-379.