Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions
	Qi Juan 1; Guo Tao 2; Li Haiyan2 ; Zhang Xueju 2; Yin Xianzhen 2; Ge Weihong 1; Zhang Jiwen2
刊名	Chinese Traditional and Herbal Drugs
	2013
卷号	44 期号:13 页码:1801-1806
关键词	aqueous extract of Coptidis Rhizoma Caco-2 monolayer model multi-component interactions apparent permeability coefficient data fitting
ISSN号	0253-2670
其他题名	黄连多组分在Caco-2细胞单层模型的吸收及其相互作用
文献子类	Article
英文摘要	Objective To research the correlation between compositions and absorption of the multi-components in Coptidis Rhizoma and to explore the methods suitable for identifying the interactions of multi-components in Coptidis Rhizoma during the absorption process. Methods Samples of various compositions by their different combinations of each component in Coptidis Rhizoma were designed and prepared using Caco-2 monolayer model. Using HPLC method for the simultaneous quantitative determination, taking the inherent apparent permeability coefficients (P_(app)) by the individual transport of each component as reference, the least square multi-linear regression was used for data fitting to obtain the correlation between interaction intensity of P_(app) and concentration of each component by their different combinations and to analyze the interaction type and intensity of multi-components during the absorption. Results The quantitative relationship of multi-component interactions for coptisine, jatrorrhizine, berberine, and palmatine was obtained, respectively. The main contributors for the multi-component interaction, including single component and interactive products of the different components, were also identified. The quantitative relationship affecting the absorption was also obtained. Conclusion A well-designed method for studying the multi-component interactions of Coptidis Rhizoma using mathematical method is practicable.
资助项目	国家科技重大专项资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4888008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267768]
专题	药物制剂研究中心
通讯作者	Zhang Jiwen
作者单位	1.Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Qi Juan,Guo Tao,Li Haiyan,et al. Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions[J]. Chinese Traditional and Herbal Drugs,2013,44(13):1801-1806.
APA	Qi Juan.,Guo Tao.,Li Haiyan.,Zhang Xueju.,Yin Xianzhen.,...&Zhang Jiwen.(2013).Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions.Chinese Traditional and Herbal Drugs,44(13),1801-1806.
MLA	Qi Juan,et al."Absorption of multi-components from Coptidis Rhizoma in Caco-2 monolayer model and their interactions".Chinese Traditional and Herbal Drugs 44.13(2013):1801-1806.