Research progress on architecture of dosage forms using synchrotron radiation X-ray microtomography

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Research progress on architecture of dosage forms using synchrotron radiation X-ray microtomography
	Yang Shuo 2; Yin XianZhen 2; Li HaiYan2 ; He Jun 1; Zhang JiWen2
刊名	Chinese Bulletin of Life Sciences
	2013
卷号	25 期号:8 页码:794-802
关键词	synchrotron radiation X-ray microtomography visualization architecture of pharmaceutical dosage forms drug release mechanism
ISSN号	1004-0374
其他题名	同步辐射显微CT研究药物制剂结构的进展
文献子类	Review
英文摘要	As the element of innovation for the drug delivery system, the architecture of the solid pharmaceutical dosage forms is the ground work to have an optimized drug delivery. With the high resolution of micron and submicron, the synchrotron radiation X-ray microtomography (SR-muCT) technique can show the static threedimensional morphology and the structural characteristics of the solid dosage forms, such as powders, particulate drug delivery systems and tablets. Furthermore, the SR-muCT can correlate the dynamic structure transformation of the pharmaceutical dosage forms during the drug release phase with the drug release kinetics. Therefore, its possible to identify the significant structural factors governing the drug release rate of the controlled/sustained release systems, which can provide new measure and novel methodologies for the design and quality control of drug delivery systems. This article reviews the advances and applications in characterization of pharmaceutical preparations. China has commenced the SR-muCT researches in structural characterization of powders, internal and microstructure of pharmaceutical preparations and structure based drug release kinetics, e.g., the identification of crystal polymorphs, quantitative profiling of mixing and segregation of granules, fractal analysis of complicated structure, the hydration dynamic characteristics of poorly water-soluble drugs in gel forming matrix tablets and the three dimensional release kinetics of monolith osmotic pump tablets.
资助项目	国家自然科学基金项目[00000000]
WOS研究方向	Genetics & Heredity (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4920715
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267762]
专题	药物制剂研究中心
通讯作者	Zhang JiWen
作者单位	1.Guizhou Province Biochemistry Engineering Centre, Guiyang, Guizhou 550025, China. 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;
推荐引用方式 GB/T 7714	Yang Shuo,Yin XianZhen,Li HaiYan,et al. Research progress on architecture of dosage forms using synchrotron radiation X-ray microtomography[J]. Chinese Bulletin of Life Sciences,2013,25(8):794-802.
APA	Yang Shuo,Yin XianZhen,Li HaiYan,He Jun,&Zhang JiWen.(2013).Research progress on architecture of dosage forms using synchrotron radiation X-ray microtomography.Chinese Bulletin of Life Sciences,25(8),794-802.
MLA	Yang Shuo,et al."Research progress on architecture of dosage forms using synchrotron radiation X-ray microtomography".Chinese Bulletin of Life Sciences 25.8(2013):794-802.