Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine

doi:10.1016/j.dmpk.2015.10.005

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	Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine
	Li, Xiuxue 1,4; Cheng, Chen 3,4; Wang, Fengqing 4; Huang, Yuhong 2; Jia, Weiwei 4; Olaleye, Olajide E.4; Li, Meijuan 4; Li, Yanfen 2; Li, Chuan1,3,4
刊名	DRUG METABOLISM AND PHARMACOKINETICS
	2016-02
卷号	31 期号:1 页码:95-98
关键词	XueBiJing injection Salvia miltiorrhiza roots Danshen Catechol Pharmacokinetics Sepsis
ISSN号	1347-4367
DOI	10.1016/j.dmpk.2015.10.005
文献子类	Article
英文摘要	XueBiJing injection, prepared from a five-herb combination, is extensively used as add-on therapy in routine sepsis care in China. Catechols, derived from the component herb Salvia miltiorrhiza roots (Danshen), are probably important because of their reported antiseptic properties. This study was designed to characterize pharmacokinetics of major circulating Danshen catechols in human subjects intravenously receiving the injection at the label doses. A total of 17 Danshen catechols were detected in XueBiJing injection (content level, 0.1e139.3 mmol/L). After dosing, tanshinol and salvianolic acid B exhibited relatively high levels of systemic exposure with mean elimination half-lives of 0.38 and 0.29 h, respectively. The total plasma clearance and apparent volume of distribution at steady state of tanshinol were 1.07 L/h/kg and 0.40 L/kg, respectively, whereas those of salvianolic acid B were 0.43 L/h/kg and 0.13 L/kg, respectively. Protocatechuic acid and five other catechols were also detected in plasma but at low exposure levels. Although protocatechuic aldehyde had the highest content level in the injection, like the remaining eight catechols, it was undetected in plasma. Protocatechuic aldehyde was extensively converted into protocatechuic acid and other metabolites. The information gained here facilitates understanding the roles of Danshen catechols in therapeutic actions of XueBiJing injection. Copyright (C) 2015, The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
资助项目	National Science & Technology Major Project of China 'Key New Drug Creation and Manufacturing Program'[2009ZX09304-002] ; National Science Foundation of China for Distinguished Young Scholars[30925044] ; National Natural Science Foundation of China[81503345] ; China Postdoctoral Science Foundation[2014M560169]
WOS关键词	MILTIORRHIZA ROOTS DANSHEN ; SALVIA-MILTIORRHIZA ; SYSTEMIC EXPOSURE ; DISPOSITION ; TANSHINOL
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	JAPANESE SOC STUDY XENOBIOTICS
WOS记录号	WOS:000369948600014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276163]
专题	上海药物代谢研究中心科研与新药推进处
通讯作者	Li, Chuan
作者单位	1.Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 300193, Peoples R China; 2.Tianjin Univ Tradit Chinese Med, Affiliated Hosp 2, Tianjin 300150, Peoples R China 3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Lab DMPK Res Herbal Med, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Li, Xiuxue,Cheng, Chen,Wang, Fengqing,et al. Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine[J]. DRUG METABOLISM AND PHARMACOKINETICS,2016,31(1):95-98.
APA	Li, Xiuxue.,Cheng, Chen.,Wang, Fengqing.,Huang, Yuhong.,Jia, Weiwei.,...&Li, Chuan.(2016).Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine.DRUG METABOLISM AND PHARMACOKINETICS,31(1),95-98.
MLA	Li, Xiuxue,et al."Pharmacokinetics of catechols in human subjects intravenously receiving XueBiJing injection, an emerging antiseptic herbal medicine".DRUG METABOLISM AND PHARMACOKINETICS 31.1(2016):95-98.