Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients | |
Zhang, Yi-fan![]() ![]() ![]() ![]() | |
刊名 | ACTA PHARMACOLOGICA SINICA
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2007-08 | |
卷号 | 28期号:8页码:1243-1246 |
关键词 | domperidone omeprazole maleate salt free base pharmacokinetics |
ISSN号 | 1671-4083 |
DOI | 10.1111/j.1745-7254.2007.00596.x |
文献子类 | Article |
英文摘要 | Aim: To investigate the influence of omeprazole on the pharmacokinetics of domperidone given as free base and maleate salt. Methods: An open, randomized, 2-period crossover study with a washout period of 7 d was conducted in 10 healthy Chinese, male patients. In each study period, the patients were administered a single oral dose of 10 mg domperidone as free base or maleate salt on d 1, 20 mg omeprazole twice daily on d 2 and 3, and once on d 4. A single dose of 10 mg domperidone as free base or maleate salt was taken at 4 h after administration of omeprazole on d 4. Plasma samples were collected on d 1 and 4 after the administration of domperidone, and the plasma concentrations of domperidone were determined by a sensitive liquid chromatography-tandem mass spectrometry method. Results: For free-base domperidone, pretreatment with omeprazole resulted in a 16% decrease in maximum concentration (C-max), compared with administration alone (P < 0.05). However, for maleate salt, with the exception of an increase in t(1/2), no pharmacokinetic parameters were significantly changed. When the free base and maleate salt were administered alone, no differences were found in any parameters between the 2 formulations. In contrast, when they were administered in the presence of omeprazole, the C-max of domperidone given as free base was lower (25.9%) than that given as maleate salt (P < 0.05). Conclusion: Pretreatment of omeprazole does not affect the absorption of domperidone maleate, but leads to a moderately decreased rate of absorption of the free base. |
WOS关键词 | GASTROESOPHAGEAL-REFLUX DISEASE ; INTRAGASTRIC PH ; PANTOPRAZOLE |
WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
语种 | 英语 |
CSCD记录号 | CSCD:3088160 |
出版者 | BLACKWELL PUBLISHING |
WOS记录号 | WOS:000248512000022 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/273182] ![]() |
专题 | 上海药物代谢研究中心 |
通讯作者 | Zhong, Da-fang |
作者单位 | 1.Beijing Hanmi Pharm, Beijing 101312, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yi-fan,Chen, Xiao-yan,Dai, Xiao-jian,et al. Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients[J]. ACTA PHARMACOLOGICA SINICA,2007,28(8):1243-1246. |
APA | Zhang, Yi-fan.,Chen, Xiao-yan.,Dai, Xiao-jian.,Zhang, Yi-ni.,Liu, Qi-zhi.,...&Zhong, Da-fang.(2007).Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients.ACTA PHARMACOLOGICA SINICA,28(8),1243-1246. |
MLA | Zhang, Yi-fan,et al."Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients".ACTA PHARMACOLOGICA SINICA 28.8(2007):1243-1246. |
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