Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients

doi:10.1111/j.1745-7254.2007.00596.x

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	Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients
	Zhang, Yi-fan; Chen, Xiao-yan; Dai, Xiao-jian; Zhang, Yi-ni ; Liu, Qi-zhi ; Yu, Hua-ling ; Zhong, Da-fang
刊名	ACTA PHARMACOLOGICA SINICA
	2007-08
卷号	28 期号:8 页码:1243-1246
关键词	domperidone omeprazole maleate salt free base pharmacokinetics
ISSN号	1671-4083
DOI	10.1111/j.1745-7254.2007.00596.x
文献子类	Article
英文摘要	Aim: To investigate the influence of omeprazole on the pharmacokinetics of domperidone given as free base and maleate salt. Methods: An open, randomized, 2-period crossover study with a washout period of 7 d was conducted in 10 healthy Chinese, male patients. In each study period, the patients were administered a single oral dose of 10 mg domperidone as free base or maleate salt on d 1, 20 mg omeprazole twice daily on d 2 and 3, and once on d 4. A single dose of 10 mg domperidone as free base or maleate salt was taken at 4 h after administration of omeprazole on d 4. Plasma samples were collected on d 1 and 4 after the administration of domperidone, and the plasma concentrations of domperidone were determined by a sensitive liquid chromatography-tandem mass spectrometry method. Results: For free-base domperidone, pretreatment with omeprazole resulted in a 16% decrease in maximum concentration (C-max), compared with administration alone (P < 0.05). However, for maleate salt, with the exception of an increase in t(1/2), no pharmacokinetic parameters were significantly changed. When the free base and maleate salt were administered alone, no differences were found in any parameters between the 2 formulations. In contrast, when they were administered in the presence of omeprazole, the C-max of domperidone given as free base was lower (25.9%) than that given as maleate salt (P < 0.05). Conclusion: Pretreatment of omeprazole does not affect the absorption of domperidone maleate, but leads to a moderately decreased rate of absorption of the free base.
WOS关键词	GASTROESOPHAGEAL-REFLUX DISEASE ; INTRAGASTRIC PH ; PANTOPRAZOLE
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:3088160
出版者	BLACKWELL PUBLISHING
WOS记录号	WOS:000248512000022
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273182]
专题	上海药物代谢研究中心
通讯作者	Zhong, Da-fang
作者单位	1.Beijing Hanmi Pharm, Beijing 101312, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yi-fan,Chen, Xiao-yan,Dai, Xiao-jian,et al. Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients[J]. ACTA PHARMACOLOGICA SINICA,2007,28(8):1243-1246.
APA	Zhang, Yi-fan.,Chen, Xiao-yan.,Dai, Xiao-jian.,Zhang, Yi-ni.,Liu, Qi-zhi.,...&Zhong, Da-fang.(2007).Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients.ACTA PHARMACOLOGICA SINICA,28(8),1243-1246.
MLA	Zhang, Yi-fan,et al."Influence of omeprazole on pharmacokinetics of domperidone given as free base and maleate salt in healthy Chinese patients".ACTA PHARMACOLOGICA SINICA 28.8(2007):1243-1246.