Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains

doi:10.1016/j.carbpol.2018.01.026

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains
	Li, Saijuan 1,2,3; Li, Meixia 1,2; Yue, Han 1,2,3; Zhou, Lishuang 1,2,3; Huang, Lulin 1,2; Du, Zhenyun 1,2; Ding, Kan1,2,3
刊名	CARBOHYDRATE POLYMERS
	2018-04-15
卷号	186 页码:168-175
关键词	Fructus Mori Polysaccharide Intestinal flora B. thetaiotaomicron
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2018.01.026
文献子类	Article
英文摘要	Many studies suggested that polysaccharides could impact on the gut microbiota. To discover new polysaccharides which influence intestinal beneficial bacteria, a pectin polysaccharide FMP-6-S2 with an average molecular weight of 86.83 kDa was purified from Fructus Mori. The monosaccharide residue analysis indicated that FMP-6-S2 was composed of rhamnose, galacturonic acid, galactose and arabinose in a molar ratio of 30.86: 24.78: 28.70: 15.61. The backbone of FMP-6-S2 contained 1, 4-linked alpha-GalpA and 1, 2-linked alpha-Rhap with branches substituted at C-4 position of rhamnose. The branches were composed of 1, 4-linked beta-Galp, terminal (T) - and 1, 3, 6-linked beta-Galp, T-and 1, 5-linked alpha-Araf. Bioactivity test results suggested that FMP-6-S2 and its degraded product could promote growth of intestinal bacteria, B. thetaiotaomicron, which is a dominate strain in the gut of human to benefit intestinal mucosa. These results suggested that FMP-6-S2 and its degraded product might improve human wellness by modulating B. thetaiotaomicron.
资助项目	State Key Program of National Natural Science Foundation of China[31230022] ; New Drug Creation and Manufacturing Program[2017ZX09305-003] ; Ministry of Science and Technology, the People Republic of China[00000000] ; Program of Shanghai Subject Chief Scientist[16XD1404500]
WOS关键词	CHRYSANTHEMUM-MORIFOLIUM FLOWERS ; HUMAN GUT SYMBIONT ; BACTEROIDES-THETAIOTAOMICRON ; MULBERRY FRUIT ; ANTIOXIDANT ACTIVITY ; IN-VITRO ; ALBA L. ; MICROBIOTA ; GROWTH ; METABOLISM
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000426360800019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279801]
专题	药理学第三研究室
通讯作者	Li, Meixia; Ding, Kan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Zunyi Med Univ, Sch Pharm, 201 Dalian Rd, Zunyi 563003, Peoples R China;
推荐引用方式 GB/T 7714	Li, Saijuan,Li, Meixia,Yue, Han,et al. Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains[J]. CARBOHYDRATE POLYMERS,2018,186:168-175.
APA	Li, Saijuan.,Li, Meixia.,Yue, Han.,Zhou, Lishuang.,Huang, Lulin.,...&Ding, Kan.(2018).Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains.CARBOHYDRATE POLYMERS,186,168-175.
MLA	Li, Saijuan,et al."Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains".CARBOHYDRATE POLYMERS 186(2018):168-175.