Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans | |
Jiang, Meng-Yuan1,3; Zhang, Ling1,3; Dong, Ze-Jun1; Yang, Zhu-Liang1; Leng, Ying2; Liu, Ji-Kai1 | |
刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN |
2010-01 | |
卷号 | 58期号:1页码:113-116 |
关键词 | vibralactone 11 beta-hydroxysteroid dehydrogenase activity Boreostereum vibrans |
ISSN号 | 0009-2363 |
DOI | 10.1248/cpb.58.113 |
文献子类 | Article |
英文摘要 | Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of I was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound I showed weak inhibitory activities against isozymes of 11 beta-hydroxysteroid dehydrogenases (HSD) with IC50 values of 85.7 mu M (human HSD1), 295.2 mu M (mouse HSD1), and 87.1 mu M (human HSD2). |
资助项目 | National Basic Research Program of China[2009CB522300] ; National Natural Sciences Foundation of China[30830113] ; Chinese Academy of Sciences[KSCX1-YW-R-24] ; Chinese Academy of Sciences[KSCX2-YW-G-025] |
WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
语种 | 英语 |
出版者 | PHARMACEUTICAL SOC JAPAN |
WOS记录号 | WOS:000273168400022 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/279008] |
专题 | 药理学第一研究室 |
通讯作者 | Liu, Ji-Kai |
作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; |
推荐引用方式 GB/T 7714 | Jiang, Meng-Yuan,Zhang, Ling,Dong, Ze-Jun,et al. Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(1):113-116. |
APA | Jiang, Meng-Yuan,Zhang, Ling,Dong, Ze-Jun,Yang, Zhu-Liang,Leng, Ying,&Liu, Ji-Kai.(2010).Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans.CHEMICAL & PHARMACEUTICAL BULLETIN,58(1),113-116. |
MLA | Jiang, Meng-Yuan,et al."Vibralactones D-F from Cultures of the Basidiomycete Boreostereum vibrans".CHEMICAL & PHARMACEUTICAL BULLETIN 58.1(2010):113-116. |
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