Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex

doi:10.1021/ic100638u

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	Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex
	Xie, Mingjin 2; Liu, Weiping 3; Lou, Liguang1 ; Chen, Xizhu 3; Ye, Qingsong 3; Yu, Yao 3; Chang, Qiaowen 3; Hou, Shuqian 3
刊名	INORGANIC CHEMISTRY
	2010-07-05
卷号	49 期号:13 页码:5792-5794
ISSN号	0020-1669
DOI	10.1021/ic100638u
文献子类	Article
英文摘要	An unexpected and unusual dimeric platinum(II) tetracarboxylate complex was obtained by the reaction of cis-[Pt(NH3)(2)I-2] with disilver dicarboxylate. The complex exhibits greater in vitro anticancer activity and lower toxicity in mice than its parent compound, carboplatin, and is therefore worthy of further evaluation as a potential antitumor dinuclear platinum agent.
资助项目	National Natural Science Foundation of China[20861004] ; National Key New Drug Contrive Project[2009ZX09103-109] ; Provincial Natural Science Foundation of Yunnan[2008CCO20] ; Provincial Natural Science Foundation of Yunnan[2009CD006]
WOS关键词	PLATINUM(II) COMPLEXES ; X-RAY ; CRYSTAL-STRUCTURES ; AGENTS ; CISPLATIN ; DESIGN
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000279211500006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278836]
专题	药理学第一研究室
通讯作者	Liu, Weiping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Yunnan Univ, Dept Chem, Kunming 650091, Peoples R China; 3.Kunming Inst Precious Met, State Key Lab Adv Technol PGMs, Kunming 650106, Peoples R China;
推荐引用方式 GB/T 7714	Xie, Mingjin,Liu, Weiping,Lou, Liguang,et al. Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex[J]. INORGANIC CHEMISTRY,2010,49(13):5792-5794.
APA	Xie, Mingjin.,Liu, Weiping.,Lou, Liguang.,Chen, Xizhu.,Ye, Qingsong.,...&Hou, Shuqian.(2010).Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex.INORGANIC CHEMISTRY,49(13),5792-5794.
MLA	Xie, Mingjin,et al."Unusual Dimeric Chemical Structure for a Carboplatin Analogue as a Potential Anticancer Complex".INORGANIC CHEMISTRY 49.13(2010):5792-5794.