A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum

doi:10.1016/j.carres.2012.02.029

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum
	Dong, Qun 1; Wang, Ying 1; Shi, Lei 1; Yao, Jian 1; Li, Jie 1; Ma, Fangli 2; Ding, Kan1
刊名	CARBOHYDRATE RESEARCH
	2012-05-15
卷号	353 页码:100-105
关键词	Ganoderma lucidum beta-(1 -> 6)-Glucan Polysaccharide Structure
ISSN号	0008-6215
DOI	10.1016/j.carres.2012.02.029
文献子类	Article
英文摘要	Ganoderma lucidum is an edible and medicinal mushroom used widely in East Asia. In recent years, its spores have been used as a supplement in combination with other forms of antitumor therapies. The cell wall of Ganoderma lucidum spores contains a high amount of polysaccharides. In this study, a neutral polysaccharide, GLSA50-1B, was isolated from sporoderm-broken spores of Ganoderma lucidum, by hot-water extraction, graded ethanol precipitation, anion-exchange chromatography, and gel permeation chromatography. Using sugar compositional analysis, methylation analysis, partial acid hydrolysis, acetolysis, and NMR and ESI-MS spectroscopy, GLSA50-1B was elucidated to be a novel beta-D-glucan featured by a 1,6-linked beta-D-Glcp backbone with different length of branches consisting of terminal and 1,4-linked Glcp residues, attached to O-4 of alternative Glc residues in the backbone. (C) 2012 Elsevier Ltd. All rights reserved.
资助项目	National High Technology Project (863)[2007AA10Z341] ; Key New Drug Creation and Manufacturing Program[2009ZX09501-011] ; Key New Drug Creation and Manufacturing Program[2009ZX09103-071] ; Key New Drug Creation and Manufacturing Program[2009ZX09301-001]
WOS关键词	STRUCTURAL-CHARACTERIZATION ; FR. KARST ; POLYSACCHARIDE ; CELLS ; CYTOKINES ; FEATURES ; VEGF ; MICE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000304053900014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278076]
专题	药理学第三研究室
通讯作者	Dong, Qun
作者单位	1.Chinese Acad Sci & Infinitus, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; 2.Lee Kum Kee Hlth Prod Grp Ltd, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Dong, Qun,Wang, Ying,Shi, Lei,et al. A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum[J]. CARBOHYDRATE RESEARCH,2012,353:100-105.
APA	Dong, Qun.,Wang, Ying.,Shi, Lei.,Yao, Jian.,Li, Jie.,...&Ding, Kan.(2012).A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum.CARBOHYDRATE RESEARCH,353,100-105.
MLA	Dong, Qun,et al."A novel water-soluble beta-D-glucan isolated from the spores of Ganoderma lucidum".CARBOHYDRATE RESEARCH 353(2012):100-105.