Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells

doi:10.1016/j.bmcl.2014.03.019

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells
	Yan, Chen 2,3,4; Huang, Li 1; Liu, Hong-Chun5 ; Chen, Duo-Zhi 2; Liu, Hai-Yang 2; Li, Xiao-Hui 2; Zhang, Yu 2; Geng, Mei-Yu5 ; Chen, Quan 1; Hao, Xiao-Jiang 2
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2014-04-15
卷号	24 期号:8 页码:1884-1888
关键词	Spiramine derivative alpha,beta-Unsaturated ketone Bax(-/-)/Bak(-/-) cells Apoptosis Cytotoxicity
ISSN号	0960-894X
DOI	10.1016/j.bmcl.2014.03.019
文献子类	Article
英文摘要	Spiramine C-D, the atisine-type diterpenoid alkaloids isolated from the Chinese herbal medicine Spiraea japonica complex, are shown to have anti-inflammatory effects in vitro. In this study, we report that spiramine derivatives of spiramine C-D bearing alpha,beta-unsaturated ketone induce apoptosis of Bax (/) /Bak (/) MEFs cell, which is positively corresponding their cytotoxicity of tumor cell lines including multidrug resistance MCF-7/ADR. The results indicated that oxazolidine ring is necessary, and derivatives bearing double 'Michael reaction acceptor' group would significantly increased activities both of inducing apoptosis of Bax (/) /Bak (/) cells and cytotoxicity of tumor cells. The result indicated that spiramine derivative with alpha,beta-unsaturated ketone group is a new anti-cancer agent with a capability of inducing apoptosis of cancer cells in Bax(-/-)/Bak(-/-) independent manner. (C) 2014 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[U1032603]
WOS关键词	RESISTANCE
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000333579500004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277113]
专题	药理学第一研究室
通讯作者	Chen, Quan
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China; 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China; 4.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Beijing 100101, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yan, Chen,Huang, Li,Liu, Hong-Chun,et al. Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(8):1884-1888.
APA	Yan, Chen.,Huang, Li.,Liu, Hong-Chun.,Chen, Duo-Zhi.,Liu, Hai-Yang.,...&Hao, Xiao-Jiang.(2014).Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(8),1884-1888.
MLA	Yan, Chen,et al."Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.8(2014):1884-1888.