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	Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}
	Jiang, Jing2; Lei, Jing1; Chen, Xi-Zhu2; Lou, Li-Guang3; Ye, Qing-Song2; Chang, Qiao-Wen2; Xu, Yong-Ping3; Liu, Wei-Ping2
刊名	RESEARCH ON CHEMICAL INTERMEDIATES
	2015-09
卷号	41期号:9页码:6149-6155
关键词	Platinum complexes Heptaplatin Synthesis Anticancer
ISSN号	0922-6168
DOI	10.1007/s11164-014-1728-0
文献子类	Article
英文摘要	A new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)} has been synthesized, characterized by elemental analysis, MS, IR, and H-1, C-13 NMR, and evaluated for in vitro anticancer activity in four human cancer cell lines. The stability of the derivative in water was also investigated by monitoring the changes of H-1 NMR in D2O. The results reveal that the new derivative has good solubility and stability in water and also shows high anticancer activity against gastric cancer cells, ovarian cancer cells, and colon cancer cells. Therefore, it is worthy of further evaluation for in vivo antitumor activity and toxicity.
资助项目	National Science Foundation of P. R. China[21161010] ; China National Research and Development Program[2012BAE06B08]
WOS关键词	PLATINUM COMPLEXES ; ANTITUMOR-ACTIVITY ; DESIGN ; ANALOG ; DRUGS
WOS研究方向	Chemistry
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000361140200017
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276414]
专题	药理学第一研究室
通讯作者	Liu, Wei-Ping
作者单位	1.Hunan Normal Univ, Sch Chem, Changsha 410081, Hunan, Peoples R China; 2.Kunming Inst Precious Met, State Key Lab Adv Technol PGM, Kunming 50106, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Jing,Lei, Jing,Chen, Xi-Zhu,et al. Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}[J]. RESEARCH ON CHEMICAL INTERMEDIATES,2015,41(9):6149-6155.
APA	Jiang, Jing.,Lei, Jing.,Chen, Xi-Zhu.,Lou, Li-Guang.,Ye, Qing-Song.,...&Liu, Wei-Ping.(2015).Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}.RESEARCH ON CHEMICAL INTERMEDIATES,41(9),6149-6155.
MLA	Jiang, Jing,et al."Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}".RESEARCH ON CHEMICAL INTERMEDIATES 41.9(2015):6149-6155.

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