Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand

doi:10.1016/S0091-3057(03)000089-3

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand
	Liu, ZH; Jin, WQ; Zhang, HP; Chen, XJ; Jin, GZ
刊名	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
	2003-05
卷号	75 期号:2 页码:289-294
关键词	l-12-chloroscoulerine morphine SCH23390 PPHT dopamine receptors conditioned place preference
ISSN号	0091-3057
DOI	10.1016/S0091-3057(03)000089-3
文献子类	Article
英文摘要	The effect of 1-12-chloroscoulerine (I-CSL), a novel ligand with dual dopamine D-1 receptor agonistic and D-2 receptor antagonistic actions, on the development of morphine-induced conditioned place preference (CPP) was investigated in mice. Morphine (10 mg/kg)-induced place preference was dose dependently suppressed by coadministration of l-CSL (5, 10 and 20 mg/kg), which induced neither place preference nor place aversion when administered alone at a dose of 20 mg/kg. The D, receptor antagonist SCH23390 (0.1 mg/kg) suppressed, whereas the D2 receptor agonist (+/-)-2-(N-phenylethyl-N-propyl)-amino-5-hydroxytetralin (PPHT) (0.5 mg/kg) had no influence on the development of morphine-induced place preference. However, SCH23390 (0.1 mg/kg) did not affect, whereas PPHT (0.5 mg/kg) reversed the suppressive effect of I-CSL on the development of morphine-induced place preference. These results indicate that I-CSL suppresses the development of place preference of morphine by blocking D2 receptors. (C) 2003 Elsevier Science Inc. All rights reserved.
WOS关键词	12-CHLOROSCOULERINE ENANTIOMERS ; REINFORCING PROPERTIES ; REWARD PATHWAYS ; D2 RECEPTORS ; MICE ; AMPHETAMINE ; COCAINE ; RATS ; BLOCKADE ; SYSTEM
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000184478400007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274240]
专题	药理学第一研究室
通讯作者	Jin, WQ
作者单位	Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Liu, ZH,Jin, WQ,Zhang, HP,et al. Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2003,75(2):289-294.
APA	Liu, ZH,Jin, WQ,Zhang, HP,Chen, XJ,&Jin, GZ.(2003).Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,75(2),289-294.
MLA	Liu, ZH,et al."Suppression of morphine-induced conditioned place preference by l-12-chloroscoulerine, a novel dopamine receptor ligand".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 75.2(2003):289-294.