Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues

doi:10.1016/j.bmc.2007.05.045

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	Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues
	Shao, Yong ; Ding, Hong; Tang, Weidong ; Lou, Liguang; Hu, Lihong
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2007-08-01
卷号	15 期号:15 页码:5061-5075
关键词	antitumor anhydrovinblastine derivatives carbamate cytotoxicity
ISSN号	0968-0896
DOI	10.1016/j.bmc.2007.05.045
文献子类	Article
英文摘要	A series of 3-demethoxycarbonyl-3-carbamate methyl anhydrovinblastine derivatives (compounds 8b-32b) were designed, synthesized, and evaluated for their inhibition activities against human non-small cell lung cancer cell line (A549) and a human cervix epithelial adenocarcinoma cell line (HeLa). The structure-activity relationships of this new series are described in this paper. Cytotoxicity data revealed that the size of substituents and substitution position had important influence on cytotoxic activity. On two cell lines, compounds (8b and 30b) had more potent cytotoxic activity than the lead compound (le, AVLB). The preliminary antitumor studies of 8b in vivo showed that it might be promising for the development of new antitumor agents. (c) 2007 Elsevier Ltd. All rights reserved.
WOS关键词	VINCA ALKALOIDS ; CLINICAL DEVELOPMENT ; CATHARANTHUS-ROSEUS ; DERIVATIVES ; VINDOLINE ; VINFLUNINE
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000247714900002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273183]
专题	药理学第一研究室上海中药现代化研究中心
通讯作者	Lou, Liguang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Shao, Yong,Ding, Hong,Tang, Weidong,et al. Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(15):5061-5075.
APA	Shao, Yong,Ding, Hong,Tang, Weidong,Lou, Liguang,&Hu, Lihong.(2007).Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues.BIOORGANIC & MEDICINAL CHEMISTRY,15(15),5061-5075.
MLA	Shao, Yong,et al."Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues".BIOORGANIC & MEDICINAL CHEMISTRY 15.15(2007):5061-5075.