FS-108,an Hsp90 inhibitor,impairs survival and motility of oncogene addicted cancer cells

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	FS-108,an Hsp90 inhibitor,impairs survival and motility of oncogene addicted cancer cells
	Ping Fangfang 3; Wang Yueqin 2; Zhang Minmin2 ; Shi Feng 1; Chen Danqi1 ; Ding Jian2
刊名	Chinese Pharmacological Bulletin
	2016
卷号	32 期号:10 页码:1357-1363
关键词	Hsp90 caspase-3 Hsp90 EBC-1 and A375 cells G_2/M arrest apoptosis Caspase-3 migration
ISSN号	1001-1978
其他题名	Hsp90抑制剂FS-108抑制癌基因依赖肿瘤细胞增殖及运动的机制研究
文献子类	Review
英文摘要	Aim To investigate the anti-tumor effects of FS-108 an Hsp90 inhibitor, on oncogene addicted EBC-1 and A375 cells. Methods SRB assay was performed to investigate cell proliferation. Immunoblot was conducted to investigate the specific proteins. FACS was conducted to test cell cycle distribution and apoptosis. Transwell assay was conducted to investigate cell motility. Results FS-108 significantly suppressed cell proliferation of EBC-1 and A375 cancer cells with IC_(50) at 25.53 nmol ? L~(-1) and 30.02 nmol ? L~(-1) respectively. FS-108 treatment triggered the degradation of key client proteins such as c-Met and B-Raf and thereby reduced their downstream AKT and ERK signaling pathways. The FACS analysis results demonstrated that FS-108 treatment induced G_2/M phase arrest and apoptosis significantly. Furthermore, FS-108 inhibited the migration of EBC-1 and A375 cells. Conclusion As a potent Hsp90 inhibitor, FS-108 can inhibit oncogene addicted cancer cells proliferation through induction of G_2/M phase arrest and apoptosis.
资助项目	国家自然科学基金资助项目[00000000]
WOS研究方向	General & Internal Medicine ; Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5820180
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269233]
专题	药理学第一研究室
通讯作者	Ding Jian
作者单位	1.Synthetic Organic and Medicinal Chemistry Laboratory, Shanghai Institute of Material Medicine, University of Chinese Academy of Sciences, Shanghai 201203, China. 2.State Key Laboratory of Drug Research, Shanghai Institute of Material Medicine, University of Chinese Academy of Sciences, Shanghai 201203, China.; 3.College of Life Science, Shanghai University, State Key Laboratory of Drug Research, Shanghai 200444, China.;
推荐引用方式 GB/T 7714	Ping Fangfang,Wang Yueqin,Zhang Minmin,et al. FS-108,an Hsp90 inhibitor,impairs survival and motility of oncogene addicted cancer cells[J]. Chinese Pharmacological Bulletin,2016,32(10):1357-1363.
APA	Ping Fangfang,Wang Yueqin,Zhang Minmin,Shi Feng,Chen Danqi,&Ding Jian.(2016).FS-108,an Hsp90 inhibitor,impairs survival and motility of oncogene addicted cancer cells.Chinese Pharmacological Bulletin,32(10),1357-1363.
MLA	Ping Fangfang,et al."FS-108,an Hsp90 inhibitor,impairs survival and motility of oncogene addicted cancer cells".Chinese Pharmacological Bulletin 32.10(2016):1357-1363.