Identification of metabolites and pharmacokinetics of mogrol in rat plasma

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	Identification of metabolites and pharmacokinetics of mogrol in rat plasma
	Liu Shangui 1; Dai Xiaojian2 ; Zhong Dafang2 ; Zhang Chaofeng 1; Chen Xiaoyan2
刊名	Acta Pharmaceutica Sinica
	2017
卷号	52 期号:9 页码:1452-1457
关键词	UHPLC-Q-TOF/MS LC-MS/MS mogrol UHPLC-Q-TOF/MS metabolite LC-MS/MS pharmacokinetics
ISSN号	0513-4870
其他题名	罗汉果醇在大鼠血浆中代谢产物鉴定及药代动力学研究
文献子类	Article
英文摘要	Mogrol is the aglycone of seven kinds of mogrosides and siamenoside I. Mogrol has drawn more attention in recent years for its anti-leukemia and anti-diabetes activities. An ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method was applied to identify the main metabolites of mogrol in rat plasma. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for determination of the main components in rat plasma. After an oral administration of 100 mg·kg~(-1) mogrol in rats, 13 metabolites were detected along the main component of parent drug in the plasma. The major metabolites were oxidated and dehydrogenated products. In this study, mogrol was quantitative analyzed using lithium carbonate reagent with high sensitivity. The assay was linear in concentration range 5.00-1 000 ng·mL~(-1) with intra- and inter- day precision within 9.3% and accuracy in range of -4.5% to 2.9%. Mogrol was absorbed into the blood very fast after oral administration, and the time to reach maximum concentration (t_(max)) was 1.67 h. The half-life (t_(1/2)) of mogrol in rats was 2.34 h, and the oral absolute bioavailability was 3.5%.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:6064064
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269196]
专题	上海药物代谢研究中心
通讯作者	Chen Xiaoyan
作者单位	1.School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Liu Shangui,Dai Xiaojian,Zhong Dafang,et al. Identification of metabolites and pharmacokinetics of mogrol in rat plasma[J]. Acta Pharmaceutica Sinica,2017,52(9):1452-1457.
APA	Liu Shangui,Dai Xiaojian,Zhong Dafang,Zhang Chaofeng,&Chen Xiaoyan.(2017).Identification of metabolites and pharmacokinetics of mogrol in rat plasma.Acta Pharmaceutica Sinica,52(9),1452-1457.
MLA	Liu Shangui,et al."Identification of metabolites and pharmacokinetics of mogrol in rat plasma".Acta Pharmaceutica Sinica 52.9(2017):1452-1457.