Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target

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	Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target
	Fu Yufeng; Wu Qingli; Yang Yifu; Zuo Jianping
刊名	Chinese Journal of Pharmacology and Toxicology
	2006
卷号	20 期号:6 页码:510-514
关键词	S-adenosyl-L-homocysteine hydrolase autoimmune diseases viruses atherosclerosis Alzheimer disease
ISSN号	1000-3002
其他题名	以S-腺苷同型半胱氨酸水解酶为潜在靶点的新药研究进展
文献子类	Review
英文摘要	S-Adenosyl-L-homocysteine hydrolase (SAHH) is a ubiquitous enzyme catalyzing the hydrolysis of S-adenosyl-L-homocysteine (AdoHcy) to adenosine and homocysteine in mammalian cells. Inhibition of SAHH has been known to result in accumulation of intracellular levels of AdoHcy, which is a potent inhibitor of all 5-adenosyl-L-methionine-dependent transmethylation reactions. Based on the observation that mammalian cells appear to be. dependent on methyla-tion for activation, SAHH has recently been selected as an attractive specific target for design of agents for immunosuppression, antiviral, treatment of atherosclerosis and Alzheimer's disease. More and more researchers have focused their attention on SAHH inhibitors because of the original chemistry structure, potent efficacy, and unique mechanisms.
资助项目	中科院知识创新项目[00000000] ; 国家自然科学基金资助项目[00000000] ; 上海科学技术委员会资助课题[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2638004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268208]
专题	药理学第一研究室
通讯作者	Zuo Jianping
作者单位	Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Fu Yufeng,Wu Qingli,Yang Yifu,et al. Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target[J]. Chinese Journal of Pharmacology and Toxicology,2006,20(6):510-514.
APA	Fu Yufeng,Wu Qingli,Yang Yifu,&Zuo Jianping.(2006).Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target.Chinese Journal of Pharmacology and Toxicology,20(6),510-514.
MLA	Fu Yufeng,et al."Advances in research of novel drugs based on S-adenosyl-L-homocysteine hydrolase as a potential target".Chinese Journal of Pharmacology and Toxicology 20.6(2006):510-514.