LC-UV/MSn analysis of related impurities of griseofulvin

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	LC-UV/MSn analysis of related impurities of griseofulvin
	DU Yue 2; YANG Huiyuan 2; DENG Pan 1; LIU Hao 2; CHEN Xiaoyan1
刊名	Chinese Journal of Pharmaceutical Analysis
	2011
卷号	31 期号:8 页码:1475-1479
关键词	antibiotic griseofulvin impurities LC-UV/ion trap mass spectrometry
ISSN号	0254-1793
其他题名	液相色谱-紫外光谱-离子阱质谱法分析灰黄霉素中的相关杂质
文献子类	Article
英文摘要	Objective:To develop an LC-UV/MS method for analysis of impurities of griseofulvin.Methods:Reversed-phase gradient chromatography was used to separate griseofulvin solution,which was detected by UV detector.The major impurities were identified by ion trap mass spectrometry equipped with ESI source in the positive ion mode.Results:Six impurities of griseofulvin,including dechlorgriseofulvin,dehydrogriseofulvin,isogriseofulvin,griseofulvic acid,4-demethylgriseofulvin and 6-demethylgriseofulvin were identified.Conclusion:The new developed method for the analysis of the related impurities in griseofulvin is useful to control the quality of griseofulvin.
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4312623
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267912]
专题	上海药物代谢研究中心
作者单位	1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.Shanghai Institute for Food and Drug Control, Shanghai 201203, China.;
推荐引用方式 GB/T 7714	DU Yue,YANG Huiyuan,DENG Pan,et al. LC-UV/MSn analysis of related impurities of griseofulvin[J]. Chinese Journal of Pharmaceutical Analysis,2011,31(8):1475-1479.
APA	DU Yue,YANG Huiyuan,DENG Pan,LIU Hao,&CHEN Xiaoyan.(2011).LC-UV/MSn analysis of related impurities of griseofulvin.Chinese Journal of Pharmaceutical Analysis,31(8),1475-1479.
MLA	DU Yue,et al."LC-UV/MSn analysis of related impurities of griseofulvin".Chinese Journal of Pharmaceutical Analysis 31.8(2011):1475-1479.