Pharmacokinetic study of fluoxetine and its active metabolite in healthy Han Chinese volunteers

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	Pharmacokinetic study of fluoxetine and its active metabolite in healthy Han Chinese volunteers
	Shi Shaojun 3; Liu Yani 3; Li Zhongfang 3; Chen Xiaoyan2 ; Zeng Fandian 1
刊名	Chinese Journal of Hospital Pharmacy
	2011
卷号	31 期号:20 页码:1686-1689
关键词	fluoxetine norfluoxetine LC-MS/MS pharmacokinetics
ISSN号	1001-5213
其他题名	氟西汀及其活性代谢产物在汉族健康人体的药动学
文献子类	Article
英文摘要	OBJECTIVE To investigate the pharmacokinetics of fluoxetine and its active metabolite norfluoxetine in healthy Han Chinese volunteers. METHODS A single oral dose of 20 mg fluoxetine hydrochloride dispersible tablets were given to 24 male healthy volunteers. The concentrations of fluoxetine and norfluoxetine in plasma were measured using a validated liquid chromatography with the tandem mass spectrometer detection (LC-MS/MS) method. The pharmacokinetic parameters were calculated with DAS ver2.0 program. RESULTS The concentration-time curves of fluoxetine and norfluoxetine were fitted to a one-compartment open model. Except for one poor metabolizer, the main pharmacokinetic parameters were as follows: t1/2 were (30. 8 7. 6) and (130. 9 42. 0)h; C_(max) were (5. 5 2. 1) and (58. 5 31.7)h; Cmax were (11. 8 3. 5) and (14. 2 5. 0)ng? mL~(-1); AUC_(0-t) were (487. 4 190. 2) and (3370. 9 1175. 8) ng?h?mL~-1; AUC_(0-) were (506. 5 208. 8) and (3537. 8 1424. 1)ng?h?mL~(-1), respectively. CONCLUSION Fluoxetine hydrochloride dispersible tablet is absorbed rapidly and eliminated slowly. Norfluoxetine is eliminated much more slowly than its parent drug. One poor metabolizer is found in these healthy volunteers.
资助项目	湖北省自然科学基金[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4358295
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267901]
专题	上海药物代谢研究中心
作者单位	1.Institute of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Center for Drug Metabolism and Pharmacokinetics Research, Shanghai 201203, China.; 3.Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.;
推荐引用方式 GB/T 7714	Shi Shaojun,Liu Yani,Li Zhongfang,et al. Pharmacokinetic study of fluoxetine and its active metabolite in healthy Han Chinese volunteers[J]. Chinese Journal of Hospital Pharmacy,2011,31(20):1686-1689.
APA	Shi Shaojun,Liu Yani,Li Zhongfang,Chen Xiaoyan,&Zeng Fandian.(2011).Pharmacokinetic study of fluoxetine and its active metabolite in healthy Han Chinese volunteers.Chinese Journal of Hospital Pharmacy,31(20),1686-1689.
MLA	Shi Shaojun,et al."Pharmacokinetic study of fluoxetine and its active metabolite in healthy Han Chinese volunteers".Chinese Journal of Hospital Pharmacy 31.20(2011):1686-1689.