Iron Metabolism in Cancer

doi:10.3390/ijms20010095

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Iron Metabolism in Cancer
	Wang, Yafang; Yu, Lei; Ding, Jian; Chen, Yi
刊名	International journal of molecular sciences
	2018-12-27
卷号	20 期号:1
ISSN号	1422-0067
DOI	10.3390/ijms20010095
文献子类	Article;Review
英文摘要	Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a considerable approach for cancer therapy. Several iron chelators and iron oxide nanoparticles (IONPs) has recently been developed for cancer intervention and presented considerable effects. This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in cancer diagnosis and therapy.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266706]
专题	药理学第一研究室
通讯作者	Wang, Yafang; Yu, Lei; Ding, Jian; Chen, Yi
作者单位	Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Wang, Yafang,Yu, Lei,Ding, Jian,et al. Iron Metabolism in Cancer[J]. International journal of molecular sciences,2018,20(1).
APA	Wang, Yafang,Yu, Lei,Ding, Jian,&Chen, Yi.(2018).Iron Metabolism in Cancer.International journal of molecular sciences,20(1).
MLA	Wang, Yafang,et al."Iron Metabolism in Cancer".International journal of molecular sciences 20.1(2018).