Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro

doi:10.1007/s11010-009-0131-4

	Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro
	Sun, Xu; Zhang, Xiao-Dong; Cheng, Gang; Hu, You-Hong; Wang, He-Yao
刊名	MOLECULAR AND CELLULAR BIOCHEMISTRY
	2009-10
卷号	330 期号:1-2 页码:181-185
关键词	Hepatic stellate cells Hsp90 inhibitor Proliferation Cell cycle
ISSN号	0300-8177
DOI	10.1007/s11010-009-0131-4
文献子类	Article
英文摘要	Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 and its analog VER-49009M, inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells. Akt expression was decreased by the treatment of Hsp90 inhibitors in CFSC cells. Based on these findings, we propose that the inhibition of Hsp90 might be a rational approach in the prevention of liver fibrosis.
资助项目	National High Technology Research and Development Program of China (863 Program)[2007 AA02Z301] ; New Drug Basic Research Program of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences[07G603L056]
WOS关键词	CHAPERONE INHIBITORS ; LIVER FIBROSIS ; CANCER ; EXPRESSION ; MECHANISMS ; AGENTS ; ALPHA
WOS研究方向	Cell Biology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000270687500019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279119]
专题	药物化学研究室药理学第三研究室
通讯作者	Hu, You-Hong
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Sun, Xu,Zhang, Xiao-Dong,Cheng, Gang,et al. Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2009,330(1-2):181-185.
APA	Sun, Xu,Zhang, Xiao-Dong,Cheng, Gang,Hu, You-Hong,&Wang, He-Yao.(2009).Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.MOLECULAR AND CELLULAR BIOCHEMISTRY,330(1-2),181-185.
MLA	Sun, Xu,et al."Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro".MOLECULAR AND CELLULAR BIOCHEMISTRY 330.1-2(2009):181-185.