Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

doi:10.1016/j.cclet.2010.01.001

	Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
	Fu, Li Qiang 1; Guo, Xing Sheng 2; Liu, Xin 1; He, Hui Li 1; Wang, Yu Ling 2; Yang, Yu She 1
刊名	CHINESE CHEMICAL LETTERS
	2010-05
卷号	21 期号:5 页码:507-510
关键词	Synthesis Pleuromutilin C-2(S)-substituted Antimicrobial activity
ISSN号	1001-8417
DOI	10.1016/j.cclet.2010.01.001
文献子类	Article
英文摘要	In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity. a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for then in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. (C) 2010 Yu She Yang Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved
WOS关键词	PATHOGENS
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000277862400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278906]
专题	药物化学研究室
通讯作者	Yang, Yu She
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Fu, Li Qiang,Guo, Xing Sheng,Liu, Xin,et al. Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(5):507-510.
APA	Fu, Li Qiang,Guo, Xing Sheng,Liu, Xin,He, Hui Li,Wang, Yu Ling,&Yang, Yu She.(2010).Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives.CHINESE CHEMICAL LETTERS,21(5),507-510.
MLA	Fu, Li Qiang,et al."Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives".CHINESE CHEMICAL LETTERS 21.5(2010):507-510.