Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids | |
Li, Yi; Xu, Ming-Hua![]() | |
刊名 | ORGANIC LETTERS
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2012-04-20 | |
卷号 | 14期号:8页码:2062-2065 |
ISSN号 | 1523-7060 |
DOI | 10.1021/ol300581n |
文献子类 | Article |
英文摘要 | An efficient and straightforward method for the preparation of highly enantiomerically enriched beta,gamma-unsaturated a-amino acid derivatives by a Lewis acid promoted diastereoselective Petasis reaction of vinylboronic acid, N-tert-butanesulfinamide, and glyoxylic acid has been developed. The synthetic utilities of the approach were demonstrated by the rapid and convenient construction of challenging cyclopenta[o]proline derivatives. |
资助项目 | National Natural Science Foundation of China[21021063] ; State Key Laboratory of Drug Research[00000000] ; National Science & Technology Major Project[00000000] ; SIMM[00000000] |
WOS关键词 | TERT-BUTANESULFINYL IMINES ; CATALYTIC ASYMMETRIC-SYNTHESIS ; PAUSON-KHAND REACTION ; ENANTIOSELECTIVE SYNTHESIS ; BIS(SULFINYL)IMIDOAMIDINE LIGANDS ; STEREOSELECTIVE-SYNTHESIS ; MEDIATED ALLYLATION ; VICINAL DIAMINES ; CHIRAL AMINES ; ENANTIOPURE |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000302990100029 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/278113] ![]() |
专题 | 药物化学研究室 药物靶标结构与功能中心 |
通讯作者 | Xu, Ming-Hua |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Yi,Xu, Ming-Hua. Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids[J]. ORGANIC LETTERS,2012,14(8):2062-2065. |
APA | Li, Yi,&Xu, Ming-Hua.(2012).Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids.ORGANIC LETTERS,14(8),2062-2065. |
MLA | Li, Yi,et al."Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids".ORGANIC LETTERS 14.8(2012):2062-2065. |
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