Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids

doi:10.1021/ol300581n

	Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids
	Li, Yi; Xu, Ming-Hua
刊名	ORGANIC LETTERS
	2012-04-20
卷号	14 期号:8 页码:2062-2065
ISSN号	1523-7060
DOI	10.1021/ol300581n
文献子类	Article
英文摘要	An efficient and straightforward method for the preparation of highly enantiomerically enriched beta,gamma-unsaturated a-amino acid derivatives by a Lewis acid promoted diastereoselective Petasis reaction of vinylboronic acid, N-tert-butanesulfinamide, and glyoxylic acid has been developed. The synthetic utilities of the approach were demonstrated by the rapid and convenient construction of challenging cyclopenta[o]proline derivatives.
资助项目	National Natural Science Foundation of China[21021063] ; State Key Laboratory of Drug Research[00000000] ; National Science & Technology Major Project[00000000] ; SIMM[00000000]
WOS关键词	TERT-BUTANESULFINYL IMINES ; CATALYTIC ASYMMETRIC-SYNTHESIS ; PAUSON-KHAND REACTION ; ENANTIOSELECTIVE SYNTHESIS ; BIS(SULFINYL)IMIDOAMIDINE LIGANDS ; STEREOSELECTIVE-SYNTHESIS ; MEDIATED ALLYLATION ; VICINAL DIAMINES ; CHIRAL AMINES ; ENANTIOPURE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000302990100029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278113]
专题	药物化学研究室药物靶标结构与功能中心
通讯作者	Xu, Ming-Hua
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Yi,Xu, Ming-Hua. Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids[J]. ORGANIC LETTERS,2012,14(8):2062-2065.
APA	Li, Yi,&Xu, Ming-Hua.(2012).Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids.ORGANIC LETTERS,14(8),2062-2065.
MLA	Li, Yi,et al."Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids".ORGANIC LETTERS 14.8(2012):2062-2065.