Rh-III-Catalysed Hydrazine-Directed C(sp(2))-H Amination of Phenidones with N-Alkyl-O-benzoyl-hydroxylamines

doi:10.1002/ejoc.201402999

	Rh-III-Catalysed Hydrazine-Directed C(sp(2))-H Amination of Phenidones with N-Alkyl-O-benzoyl-hydroxylamines
	Xue, Yu 1; Fan, Zhoulong 2,3; Jiang, Xiaolong 1; Wu, Kui 1; Wang, Meining 2,3; Ding, Chunyong2,3 ; Yao, Qizheng 1; Zhang, Ao2,3
刊名	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
	2014-11
期号	33 页码:7481-7488
关键词	C-H activation Amination Hydrazines Hydroxylamines Amines Nitrogen heterocycles
ISSN号	1434-193X
DOI	10.1002/ejoc.201402999
文献子类	Article
英文摘要	A Rh-III-catalysed ortho C-H amination of phenidones under mild conditions was developed using N-alkyl-O-benzoyl-hydroxylamines as aminating agents, and with a cyclic hydrazine moiety as a directing group, yields of up to 97% and a high functional group tolerance were observed. This strategy offers an alternative route for the synthesis of amino analogues of the 5-lipoxygenase inhibitor phenidone, and the products are valuable for further functional group transformations.
资助项目	Chinese National Sciences Foundation[81125021] ; Chinese National Sciences Foundation[81373277] ; Chinese National Sciences Foundation[81430080] ; Chinese National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program"[2012ZX09103-101-035] ; Chinese National Science & Technology Major Project on "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; "Interdisciplinary Cooperation Team" Program for Science and Technology Innovation (CAS)[00000000]
WOS关键词	C-H AMIDATION ; ROOM-TEMPERATURE ; BOND FORMATION ; PROTECTED ARYLAMINES ; CONVENIENT SYNTHESIS ; BETA-LACTAMS ; ARYL AZIDES ; ARENES ; CHLOROAMINES ; ACTIVATION
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000344799100023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276854]
专题	药物化学研究室
通讯作者	Ding, Chunyong
作者单位	1.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China; 2.Chinese Acad Sci, SIMM, SOMCL, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xue, Yu,Fan, Zhoulong,Jiang, Xiaolong,et al. Rh-III-Catalysed Hydrazine-Directed C(sp(2))-H Amination of Phenidones with N-Alkyl-O-benzoyl-hydroxylamines[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014(33):7481-7488.
APA	Xue, Yu.,Fan, Zhoulong.,Jiang, Xiaolong.,Wu, Kui.,Wang, Meining.,...&Zhang, Ao.(2014).Rh-III-Catalysed Hydrazine-Directed C(sp(2))-H Amination of Phenidones with N-Alkyl-O-benzoyl-hydroxylamines.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(33),7481-7488.
MLA	Xue, Yu,et al."Rh-III-Catalysed Hydrazine-Directed C(sp(2))-H Amination of Phenidones with N-Alkyl-O-benzoyl-hydroxylamines".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .33(2014):7481-7488.