Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

doi:10.1016/j.jfluchem.2014.06.026

	Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
	Zhu, Wei 2; Wang, Jiang2 ; Wang, Shuni 2; Gu, Zhanni 2; Luis Acena, Jose 3; Izawa, Kunisuke 4; Liu, Hong2 ; Soloshonok, Vadim A.1,3
刊名	JOURNAL OF FLUORINE CHEMISTRY
	2014-11
卷号	167 页码:37-54
关键词	Trifluoromethylation Methodology Fluorine-containing drugs Pharmaceuticals Biological activity
ISSN号	0022-1139
DOI	10.1016/j.jfluchem.2014.06.026
文献子类	Article
英文摘要	This review provides a brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF3-containing pharmaceuticals. Structural aspects of five new drug-candidates, [tafenoquine (aromatic CF3), roniciclib (heteroaromatic CF3), BAY-38-7271 (aliphatic CF3), sonidegib (O-CF3) and navitoclax (S-CF3)] currently under the development in phase II and III clinical studies, and their biological properties, therapeutic area and synthesis are critically discussed. (C) 2014 Elsevier B.V. All rights reserved.
资助项目	Ikerbasque[00000000] ; Basque Foundation for Science[00000000] ; Basque Government[SAIOTEK S-PE13UN098] ; National Natural Science Foundation of China[81025017] ; Hamari Chemicals (Osaka, Japan)[00000000]
WOS关键词	COPPER-CATALYZED TRIFLUOROMETHYLATION ; CANNABINOID RECEPTOR AGONIST ; BETA-AMINO ACIDS ; SILVER-MEDIATED TRIFLUOROMETHYLATION ; LIGHT PHOTOREDOX CATALYSIS ; ENANTIOSELECTIVE ALPHA-TRIFLUOROMETHYLATION ; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; ACHIRAL-PHASE CHROMATOGRAPHY ; HYPERVALENT IODINE REAGENT
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000345469400005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276847]
专题	药物化学研究室
通讯作者	Liu, Hong
作者单位	1.Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Univ Basque Country, Fac Chem, UPV EHU, Dept Quim Chem 1, San Sebastian 20018, Spain; 4.Hamari Chem Ltd, Higashi Yodogawa Ku, Osaka 5330024, Japan;
推荐引用方式 GB/T 7714	Zhu, Wei,Wang, Jiang,Wang, Shuni,et al. Recent advances in the trifluoromethylation methodology and new CF3-containing drugs[J]. JOURNAL OF FLUORINE CHEMISTRY,2014,167:37-54.
APA	Zhu, Wei.,Wang, Jiang.,Wang, Shuni.,Gu, Zhanni.,Luis Acena, Jose.,...&Soloshonok, Vadim A..(2014).Recent advances in the trifluoromethylation methodology and new CF3-containing drugs.JOURNAL OF FLUORINE CHEMISTRY,167,37-54.
MLA	Zhu, Wei,et al."Recent advances in the trifluoromethylation methodology and new CF3-containing drugs".JOURNAL OF FLUORINE CHEMISTRY 167(2014):37-54.