Metal-mediate reactions based formal synthesis of triptonide and triptolide

doi:10.1016/j.tetlet.2014.11.010

	Metal-mediate reactions based formal synthesis of triptonide and triptolide
	Xu, Hongtao; Tang, Huanyu; Feng, Huijin; Li, Yuanchao
刊名	TETRAHEDRON LETTERS
	2014-12-17
卷号	55 期号:51 页码:7118-7120
关键词	Diterpenoid Triptolide Triptonide Metal Synthesis
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2014.11.010
文献子类	Article
英文摘要	A formal synthesis of triptolide and triptonide has been achieved based on metal-mediate reactions. Specially, Noyori's ruthenium catalyzed enantioselective transfer hydrogenation, indium(III) catalyzed cationic polyene cyclization, palladium catalyzed carbonylation, rhodium catalyzed double bond migration, and palladium catalyzed ortho sp(2) C-H bond oxygenation reactions served as convenient entry points for the preparation of the tetracyclic building blocks and the C14 hydroxyl group. (C) 2014 Elsevier Ltd. All rights reserved.
资助项目	Shanghai Science and Technology Commission 'biomedicine technology support project', China[13431900403] ; National Natural Science Foundation of NFSC, China[81373479] ; Specific Research Construction Project of National Clinical Research Base of TCM, China[JDZX2012010]
WOS关键词	PALLADIUM-CATALYZED CARBONYLATION ; ASYMMETRIC TRANSFER HYDROGENATION ; TRIPTERYGIUM-WILFORDII ; KETONES ; (-)-TRIPTOLIDE ; ACID ; OXYGENATION ; LACTONES ; DESIGN ; ACCESS
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000347020100038
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276798]
专题	药物化学研究室
通讯作者	Li, Yuanchao
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Xu, Hongtao,Tang, Huanyu,Feng, Huijin,et al. Metal-mediate reactions based formal synthesis of triptonide and triptolide[J]. TETRAHEDRON LETTERS,2014,55(51):7118-7120.
APA	Xu, Hongtao,Tang, Huanyu,Feng, Huijin,&Li, Yuanchao.(2014).Metal-mediate reactions based formal synthesis of triptonide and triptolide.TETRAHEDRON LETTERS,55(51),7118-7120.
MLA	Xu, Hongtao,et al."Metal-mediate reactions based formal synthesis of triptonide and triptolide".TETRAHEDRON LETTERS 55.51(2014):7118-7120.