Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach

doi:10.1016/j.tetlet.2015.04.040

	Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach
	Jiao, Mingkun; Ding, Chunyong; Zhang, Ao
刊名	TETRAHEDRON LETTERS
	2015-05-20
卷号	56 期号:21 页码:2799-2802
关键词	Tanshinone I Anticancer Palladium Direct arylation C-H activation
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2015.04.040
文献子类	Article
英文摘要	A facile and efficient synthetic approach under the catalyst system of Pd(OAc)(2)/KOAc/TBAB/DMF was developed allowing for rapid preparation of 2-arylation derivatives of the natural product tanshinone I. This approach was featured by palladium-catalyzed C-C coupling through direct C-sp2-H activation at the a-position of the furan ring of tanshinone I. Compared to the literature procedures, our protocol exhibited better atom-economy and much improved yields. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81402790] ; Pujiang Talent Project from Shanghai Commission of Science and Technology[14PJ1410700]
WOS关键词	SALVIA-MILTIORRHIZA BUNGE ; C-H FUNCTIONALIZATION ; BOND ACTIVATION ; CANCER CELLS ; CRYPTOTANSHINONE ; HETEROCYCLES ; INHIBITION ; ARYLATIONS ; THIOPHENE ; APOPTOSIS
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000355036400038
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276523]
专题	药物化学研究室
通讯作者	Ding, Chunyong
作者单位	Chinese Acad Sci, SIMM, SOMCL, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiao, Mingkun,Ding, Chunyong,Zhang, Ao. Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach[J]. TETRAHEDRON LETTERS,2015,56(21):2799-2802.
APA	Jiao, Mingkun,Ding, Chunyong,&Zhang, Ao.(2015).Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach.TETRAHEDRON LETTERS,56(21),2799-2802.
MLA	Jiao, Mingkun,et al."Preparation of 2-aryl derivatives of tanshinone I through a palladium-catalyzed C-sp2-H activation/arylation approach".TETRAHEDRON LETTERS 56.21(2015):2799-2802.