Association between cigarette smoking and Parkinson's disease: A meta-analysis

doi:10.1016/j.archger.2015.08.004

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	Association between cigarette smoking and Parkinson's disease: A meta-analysis
	Li, Xiao 1,2; Li, Weihua 1; Liu, Guixia 1; Shen, Xu2 ; Tang, Yun 1
刊名	ARCHIVES OF GERONTOLOGY AND GERIATRICS
	2015-11
卷号	61 期号:3 页码:510-516
关键词	Cigarette smoking Parkinson's disease Meta-analysis Pack-year
ISSN号	0167-4943
DOI	10.1016/j.archger.2015.08.004
文献子类	Article
英文摘要	Objective: To evaluate the association of Parkinson's disease (PD) with smoking, and determine whether gender, source of controls, dose of smoking, and year of studies modify the observed effects of smoking on PD. Methods: Available publications between 1959 and 2014 from PubMed, ScienceDirect, Springer Link and Web of Science databases were searched and carefully selected. Relative risks RR of specific study were weighted to obtain a pooled RR estimate and its 95% confidence interval CI. Results: 61 case-control and 8 cohort studies were included. The pooled RR of PD was 0.59 (95% CI, 0.56-0.62) for ever smokers compared with never smokers. The stratified analyses indicated a somewhat greater impact of smoking on PD risk in cohort studies than in case-control studies, the protective effect was relatively significant in men more than in women and the inverse effect was slightly greater in hospital-based studies than in population-based studies. Furthermore, a significant inverse doseresponse relationship was observed for the number of pack-years smoked. The summary RR for those smoking more than 30 pack-years was 0.66 (95% CI, 0.49-0.88), and 0.39 (95% CI, 0.29-0.53) for those smoking less than 30 pack-years. Conclusion: The results demonstrated the inverse association between cigarette smoking and the risk of PD. We suggest that effective drugs for PD might be developed using chemical substances derived from tobacco or tobacco smoke. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
资助项目	Fundamental Research Funds for the Central Universities[WY1113007] ; 111 Project[B07023]
WOS关键词	B INHIBITORS ; RISK ; EPIDEMIOLOGY ; NICOTINE ; COHORT ; COFFEE
WOS研究方向	Geriatrics & Gerontology
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000368012900028
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276334]
专题	药理学第三研究室
通讯作者	Tang, Yun
作者单位	1.E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao,Li, Weihua,Liu, Guixia,et al. Association between cigarette smoking and Parkinson's disease: A meta-analysis[J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS,2015,61(3):510-516.
APA	Li, Xiao,Li, Weihua,Liu, Guixia,Shen, Xu,&Tang, Yun.(2015).Association between cigarette smoking and Parkinson's disease: A meta-analysis.ARCHIVES OF GERONTOLOGY AND GERIATRICS,61(3),510-516.
MLA	Li, Xiao,et al."Association between cigarette smoking and Parkinson's disease: A meta-analysis".ARCHIVES OF GERONTOLOGY AND GERIATRICS 61.3(2015):510-516.