Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

doi:10.1039/c6qo00178e

	Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes
	Li, Chunpu; Zhang, Dengyou; Zhu, Wei; Wan, Penghui; Liu, Hong
刊名	ORGANIC CHEMISTRY FRONTIERS
	2016
卷号	3 期号:9 页码:1080-1083
ISSN号	2052-4129
DOI	10.1039/c6qo00178e
文献子类	Article
英文摘要	Pd-catalyzed direct difluoroallylation of C-H bonds of benzamides with readily available Rf-Br reagents is reported. The reaction proceeds via Pd-catalyzed C-H activation, followed by reaction of the resulting intermediate with 3-bromo-3,3-difluoropropene (BDFP) in a gamma-selective fashion. The C-H functionalization process was characterized by a broad substrate scope as well as an excellent functional-group tolerance.
WOS关键词	CARBON-HYDROGEN BONDS ; CROSS-COUPLING REACTIONS ; C(SP(3))-H BONDS ; CATALYZED ARYLATION ; ALKYL-HALIDES ; PALLADIUM ; DERIVATIVES ; ALLYLATION ; ACTIVATION ; BIDENTATE
WOS研究方向	Chemistry
语种	英语
出版者	CHINESE CHEMICAL SOC
WOS记录号	WOS:000382471800002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276204]
专题	药物化学研究室
通讯作者	Liu, Hong
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Chunpu,Zhang, Dengyou,Zhu, Wei,et al. Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes[J]. ORGANIC CHEMISTRY FRONTIERS,2016,3(9):1080-1083.
APA	Li, Chunpu,Zhang, Dengyou,Zhu, Wei,Wan, Penghui,&Liu, Hong.(2016).Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes.ORGANIC CHEMISTRY FRONTIERS,3(9),1080-1083.
MLA	Li, Chunpu,et al."Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes".ORGANIC CHEMISTRY FRONTIERS 3.9(2016):1080-1083.