Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

doi:10.2174/1389450117666151209123751

	Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review
	Xie, Yuanchao 2; Ogah, Comfort Alicha 1; Jiang, Xiangrui2 ; Li, Jianfeng2 ; Shen, Jingshan2
刊名	CURRENT DRUG TARGETS
	2016
卷号	17 期号:13 页码:1560-1576
关键词	Hepatitis C virus inhibitor nucleoside NS5B polymerase prodrug SAR
ISSN号	1389-4501
DOI	10.2174/1389450117666151209123751
文献子类	Review
英文摘要	Nowadays, a large number of people in the world are suffering from chronic Hepatitis C. HCV NS5B polymerase conserved across the identified 7 HCV genotypes is considered to be the most promising target in combating HCV. During the past decade, significant progress has been made in the discovery of novel nucleoside HCV NS5B polymerase inhibitors. A potent anti-HCV drug, sofosbuvir with high cure rates has been approved. Besides, quite a few nucleoside anti-HCV agents are being evaluated in clinical trials. The purpose of this review is to present recent progress in the development of nucleoside HCV NS5B polymerase inhibitors, focusing on lead compounds that hold great promise for medicinal use and their structure-activity relationships (SARs) in order to provide guidance for future drug design and discovery.
资助项目	National Science Foundation for Young Scientists of China[21502209]
WOS关键词	ANTI-HCV AGENTS ; DEPENDENT RNA-POLYMERASE ; GENOTYPE 1 INFECTION ; PHOSPHORAMIDATE PROTIDE APPROACH ; HIGHLY POTENT INHIBITORS ; BOVINE VIRAL DIARRHEA ; REPLICATION IN-VITRO ; ANTIVIRAL ACTIVITY ; PYRIMIDINE NUCLEOSIDES ; SELECTIVE INHIBITOR
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000387084300011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276193]
专题	药物化学研究室
通讯作者	Shen, Jingshan
作者单位	1.Univ Lagos, Fac Pharm, Dept Pharmaceut Chem, Lagos, Lagos State, Nigeria 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd,Zhang Jiang Hitech Pk, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Xie, Yuanchao,Ogah, Comfort Alicha,Jiang, Xiangrui,et al. Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review[J]. CURRENT DRUG TARGETS,2016,17(13):1560-1576.
APA	Xie, Yuanchao,Ogah, Comfort Alicha,Jiang, Xiangrui,Li, Jianfeng,&Shen, Jingshan.(2016).Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review.CURRENT DRUG TARGETS,17(13),1560-1576.
MLA	Xie, Yuanchao,et al."Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review".CURRENT DRUG TARGETS 17.13(2016):1560-1576.