Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme

doi:10.1016/j.carbpol.2015.09.087

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第三研究室

	Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme
	Cong, Qifei; Chen, Huanjun; Liao, Wenfeng; Xiao, Fei; Wang, Peipei; Qin, Yi; Dong, Qun; Ding, Kan
刊名	CARBOHYDRATE POLYMERS
	2016-01-20
卷号	136 页码:899-907
关键词	Sargassum fusiforme Fucoidan Structure Anti-angiogenic activity
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2015.09.087
文献子类	Article
英文摘要	A fucoidan FP08S2 was isolated from the boiling-water extract of Sargassum fusiforme, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300. FP08S2 contained fucose, xylose, galactose, mannose, glucuronic acid, and 20.8% sulfate. The sulfate groups were attached to diverse positions of fucose, xylose, mannose, and galactose residues. The backbone of FP08S2 consisted of alternate 1,2-linked alpha-D-Manp and 1A-linked beta-D-GlcpA. Sugar composition analysis and ESI-MS revealed that the oligosaccharides from branches contained fucose, xylose, galactose, glucuronic acid and sulfate. FP08S2 could significantly inhibit tube formation and migration of human microvascular endothelial cells (HMEC-1) dose-dependently. These results suggested that the fucoidan FP08S2 from brown seaweeds S. fusiforme could be a potent anti-angiogenic agent. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025]
WOS关键词	BROWN SEAWEED ; HIZIKIA-FUSIFORME ; ANTICOAGULANT ACTIVITY ; CELLS ; POLYSACCHARIDES ; BIOACTIVITY ; ANTITUMOR ; GROWTH ; CANCER ; MICE
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000365972000106
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276176]
专题	药理学第三研究室
通讯作者	Dong, Qun
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Cong, Qifei,Chen, Huanjun,Liao, Wenfeng,et al. Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme[J]. CARBOHYDRATE POLYMERS,2016,136:899-907.
APA	Cong, Qifei.,Chen, Huanjun.,Liao, Wenfeng.,Xiao, Fei.,Wang, Peipei.,...&Ding, Kan.(2016).Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme.CARBOHYDRATE POLYMERS,136,899-907.
MLA	Cong, Qifei,et al."Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme".CARBOHYDRATE POLYMERS 136(2016):899-907.