Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme | |
Cong, Qifei; Chen, Huanjun; Liao, Wenfeng; Xiao, Fei; Wang, Peipei![]() ![]() | |
刊名 | CARBOHYDRATE POLYMERS
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2016-01-20 | |
卷号 | 136页码:899-907 |
关键词 | Sargassum fusiforme Fucoidan Structure Anti-angiogenic activity |
ISSN号 | 0144-8617 |
DOI | 10.1016/j.carbpol.2015.09.087 |
文献子类 | Article |
英文摘要 | A fucoidan FP08S2 was isolated from the boiling-water extract of Sargassum fusiforme, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300. FP08S2 contained fucose, xylose, galactose, mannose, glucuronic acid, and 20.8% sulfate. The sulfate groups were attached to diverse positions of fucose, xylose, mannose, and galactose residues. The backbone of FP08S2 consisted of alternate 1,2-linked alpha-D-Manp and 1A-linked beta-D-GlcpA. Sugar composition analysis and ESI-MS revealed that the oligosaccharides from branches contained fucose, xylose, galactose, glucuronic acid and sulfate. FP08S2 could significantly inhibit tube formation and migration of human microvascular endothelial cells (HMEC-1) dose-dependently. These results suggested that the fucoidan FP08S2 from brown seaweeds S. fusiforme could be a potent anti-angiogenic agent. (C) 2015 Elsevier Ltd. All rights reserved. |
资助项目 | National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
WOS关键词 | BROWN SEAWEED ; HIZIKIA-FUSIFORME ; ANTICOAGULANT ACTIVITY ; CELLS ; POLYSACCHARIDES ; BIOACTIVITY ; ANTITUMOR ; GROWTH ; CANCER ; MICE |
WOS研究方向 | Chemistry ; Polymer Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000365972000106 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/276176] ![]() |
专题 | 药理学第三研究室 |
通讯作者 | Dong, Qun |
作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Cong, Qifei,Chen, Huanjun,Liao, Wenfeng,et al. Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme[J]. CARBOHYDRATE POLYMERS,2016,136:899-907. |
APA | Cong, Qifei.,Chen, Huanjun.,Liao, Wenfeng.,Xiao, Fei.,Wang, Peipei.,...&Ding, Kan.(2016).Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme.CARBOHYDRATE POLYMERS,136,899-907. |
MLA | Cong, Qifei,et al."Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme".CARBOHYDRATE POLYMERS 136(2016):899-907. |
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