Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair

doi:10.1016/j.jep.2008.02.004

	Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair
	Wei, X. H.2,3; Cheng, X. M.2,3; Shen, J. S.1; Wang, Z. T.2,3
刊名	JOURNAL OF ETHNOPHARMACOLOGY
	2008-05-08
卷号	117 期号:2 页码:339-344
关键词	Yueju-Wan antidepressant activity tail suspension test forced swimming test Cyperus rotuiulus L. Ligusticum chuanxiong hort. Gardenia jasminoides Ellis. Atractylodes lancea (Thunb.) DC. Massa fermentata
ISSN号	0378-8741
DOI	10.1016/j.jep.2008.02.004
文献子类	Article
英文摘要	Aim of the study: Yueju-Wan (YJ), a traditional Chinese medicinal formula, is commonly used for the treatment of depression-related syndromes in China. This study was conducted to evaluate the antidepressant activity of YJ ethanol extract (YJ-E) and its four different fractions, the petroleum ether fraction (YJ-EA), ethyl acetate fraction (YJ-EB), n-butanol fraction (YJ-EC) and final aqueous fraction (YJ-ED). Materials and methods: Two experimental despair animal models: the mice tail suspension test (TST) and the mice forced swimming test (FST) were used to evaluate the antidepressant activity of YJ-E and its fractions. These extracts or fractions were administered orally for 7 days, while the parallel positive control was given at the same time using fluoxetine hydrochloride (FLU) in TST and imipramine hydrochloride (IMI) in FST respectively. Results: YJ-E high dose (YJ-E2), YJ-EA, YJ-EC and the positive control groups could decrease the duration of immobility in the TST and FST and have no significant changes in locomotor activity. YJ-E low dose (YJ-E1), YJ-EB, YJ-ED and the vehicle solvent (VEH) control group have no obvious effect on these same tests. Conclusions: In these despair animal models, YJ ethanol extract, the petroleum ether fraction and n-butanol fraction show potent antidepressant effects. The petroleum ether fraction and n-butanol fraction appear to be the active fractions of YJ-E. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
WOS关键词	LIGUSTICUM-CHUANXIONG ; CYPERUS-ROTUNDUS ; IN-VITRO ; BUTYLIDENEPHTHALIDE ; CHROMATOGRAPHY
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000256207700019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272920]
专题	药物化学研究室
通讯作者	Wei, X. H.
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Key Lab Standardizat Chinese Med, Minist Educ, Shanghai 201203, Peoples R China; 3.Shanghai R&D Ctr Standardizat Tradit Chinese Med, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Wei, X. H.,Cheng, X. M.,Shen, J. S.,et al. Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair[J]. JOURNAL OF ETHNOPHARMACOLOGY,2008,117(2):339-344.
APA	Wei, X. H.,Cheng, X. M.,Shen, J. S.,&Wang, Z. T..(2008).Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair.JOURNAL OF ETHNOPHARMACOLOGY,117(2),339-344.
MLA	Wei, X. H.,et al."Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair".JOURNAL OF ETHNOPHARMACOLOGY 117.2(2008):339-344.